Summary

Name FRS2
Full Name Fibroblast growth factor receptor substrate 2
Synonyms FGFR substrate 2, FGFR-signaling adaptor SNT, Suc1-associated neurotrophic factor target 1, SNT-1
Primary ID Q8WU20
Links - -
Type protein
Relations 9
Pathways Luminal Breast Cancer
Function Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding FRS2 0.766
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FRS2 0.862
Publications: 1 Organism: Rattus Norvegicus
Pathways:Luminal Breast Cancer
+ up-regulates activity img/direct-activation.png binding GRB2 0.794
Publications: 1 Organism: Rattus Norvegicus
Pathways:Luminal Breast Cancer
+ down-regulates img/direct_inhibition.png ubiquitination FRS2 0.553
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PTPN11 0.771
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FRS2 0.768
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png binding FRS2 0.661
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding GRAP 0.349
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FRS2 0.671
Publications: 1 Organism: Rattus Norvegicus