Summary

Name ZFPM2
Full Name Zinc finger protein ZFPM2
Synonyms Friend of GATA protein 2, FOG-2, Friend of GATA 2, hFOG-2, Zinc finger protein 89B, Zinc finger protein multitype 2 | FOG2, ZNF89B
Primary ID Q8WW38
Links - -
Type protein
Relations 1
Function Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity).

Viewer

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding GATA4 0.773
Publications: 1 Organism: Mus Musculus