Summary

Name APH1B
Full Name Gamma-secretase subunit APH-1B
Synonyms APH-1b, Aph-1beta, Presenilin-stabilization factor-like | PSFL
Primary ID Q8WW43
Links - -
Type protein
Relations 4
Function Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding PSEN2 0.904
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png binding NCSTN 0.938
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png binding PSEN1 0.906
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PSENEN 0.94
Publications: 1 Organism: Homo Sapiens