Summary

Name BAP1
Full Name Ubiquitin carboxyl-terminal hydrolase BAP1
Synonyms BRCA1-associated protein 1, Cerebral protein 6 | KIAA0272
Primary ID Q92560
Links - -
Type protein
Relations 4
Function Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (PubMed:12485996, PubMed:18757409, PubMed:20436459, PubMed:25451922). Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459, PubMed:25451922). Does not deubiquitinate monoubiquitinated histone H2B (PubMed:20436459). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains (PubMed:19188440, PubMed:19815555). Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 (PubMed:19188440, PubMed:19815555). Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination (PubMed:19117993). It however does not mediate deubiquitination of BRCA1 and BARD1 (PubMed:19117993). Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950). Acts as a tumor suppressor (PubMed:9528852).

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CDKN2B 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding ASXL3 0.55
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Proliferation 0.7
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by stabilization img/direct-activation.png binding KEAP1 0.2
Publications: 1 Organism: Homo Sapiens