Summary

Name MAML1
Full Name Mastermind-like protein 1
Synonyms Mam-1 | KIAA0200
Primary ID Q92585
Links - -
Type protein
Relations 20
Function Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation MAML1 0.17
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding, relocalization CDK8
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization, binding EP300 0.34
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization CCNT1 0.25
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png acetylation HIST1H4A 0.66
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NOTCH1 0.54
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation HIST1H3A 0.29
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding TP53 0.01
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png binding MEF2C 0.59
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png binding CTNNB1 0.07
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png binding NOTCH4 0.52
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH1 0.54
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH2 0.65
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding NOTCH3 0.41
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RBPJ 0.91
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png acetylation MAML1 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization CCNC 0.20
Publications: 1 Organism: Homo Sapiens