Summary

Name NECTIN2
Full Name Nectin-2
Synonyms Herpes virus entry mediator B, Herpesvirus entry mediator B, HveB, Nectin cell adhesion molecule 2, Poliovirus receptor-related protein 2 | HVEB, PRR2, PVRL2
Primary ID Q92692
Links - -
Type protein
Relations 2
Function Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation NECTIN2 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png binding CD226 0.2
Publications: 1 Organism: Homo Sapiens