Summary

Name SEMA4D
Full Name Semaphorin-4D
Synonyms A8, BB18, GR3 | C9orf164, CD100, SEMAJ
Primary ID Q92854
Links - -
Type protein
Relations 1
Function Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703).

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Relations

Regulator Mechanism target score ℹ
+ SEMA4Dup-regulates img/direct-activation.png binding PLXNB1 0.802
Publications: 1 Organism: Homo Sapiens