Summary

Name USP9X
Full Name Probable ubiquitin carboxyl-terminal hydrolase FAF-X
Synonyms Deubiquitinating enzyme FAF-X, Fat facets in mammals, hFAM, Fat facets protein-related, X-linked, Ubiquitin thioesterase FAF-X, Ubiquitin-specific protease 9, X chromosome, Ubiquitin-specific-processing protease FAF-X | DFFRX, FAM, USP9
Primary ID Q93008
Links - -
Type protein
Relations 12
Pathways Ubiquitin activation
Function Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Involved in axonal growth and neuronal cell migration (PubMed:16322459, PubMed:18254724, PubMed:19135894, PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein ARNTL/BMAL1 via its deubiquitinating activity (PubMed:29626158).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png deubiquitination SMAD4 0.63
Publications: 3 Organism: Homo Sapiens, Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation USP9X 0.274
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation USP9X 0.284
Publications: 1
+ down-regulates quantity by destabilization img/direct_inhibition.png dephosphorylation USP9X 0.2
Publications: 1
+ up-regulates quantity img/direct-activation.png cleavage RPS27A 0.477
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ down-regulates activity img/direct_inhibition.png deubiquitination EPS15 0.277
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png cleavage UBA52 0.587
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ up-regulates quantity by stabilization img/direct-activation.png deubiquitination SMN1 0.287
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png cleavage Ubiquitin 0.627
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ up-regulates quantity by stabilization img/direct-activation.png deubiquitination WT1 0.2
Publications: 1