3.0
Summary
| Name |  ROBO3
|
| Full Name | Roundabout homolog 3 |
| Synonyms | Roundabout-like protein 3 |
| Primary ID | Q96MS0 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Pathways | Axon guidance |
| Function | Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube (By similarity). In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (By similarity). Required for hindbrain axon midline crossing (PubMed:15105459). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ROBO3 | up-regulates quantity by expression 
post transcriptional regulation
|
CFL1 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| Pathways: | Axon guidance | |||
| + | SLIT2 | up-regulates activity
binding
|
ROBO3 | 0.651 |
| Publications: | 1 | Organism: | In Vitro | |
| Pathways: | Axon guidance | |||