Summary

Name YTHDC1
Full Name YTH domain-containing protein 1
Synonyms Splicing factor YT521, YT521-B | KIAA1966, YT521
Primary ID Q96MU7
Links - -
Type protein
Relations 1
Function Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:25242552, PubMed:26318451, PubMed:26876937, PubMed:28984244). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:25242552, PubMed:26318451). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation YTHDC1 0.309
Publications: 1 Organism: Homo Sapiens