Summary

Name SLC46A1
Full Name Proton-coupled folate transporter
Synonyms G21, Heme carrier protein 1, PCFT/HCP1, Solute carrier family 46 member 1 | HCP1, PCFT
Primary ID Q96NT5
Links - -
Type protein
Relations 3
Function Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme.

Viewer

Relations

Regulator Mechanism target score
+ up-regulates quantity img/direct-activation.png relocalization heme 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SLC46A1 0.347
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png relocalization dihydrofolate(2-) 0.8
Publications: 1 Organism: Homo Sapiens