Summary

Name WDR24
Full Name GATOR complex protein WDR24
Synonyms WD repeat-containing protein 24 | C16orf21
Primary ID Q96S15
Links - -
Type protein
Relations 1
Function As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).

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Relations

Regulator Mechanism target score ℹ
+ WDR24form complex img/form-complex.png binding GATOR2 0.905
Publications: 1 Organism: Homo Sapiens