Summary

Name RANBP9
Full Name Ran-binding protein 9
Synonyms RanBP9, BPM-L, BPM90, Ran-binding protein M, RanBPM, RanBP7 | RANBPM
Primary ID Q96S59
Links - -
Type protein
Relations 2
Function May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and actin cytoskeleton rearrangement (PubMed:18710924). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). May be involved in signaling of ITGB2/LFA-1 and other integrins (PubMed:14722085). Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway (PubMed:12147692). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (PubMed:12361945, PubMed:18222118). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity (PubMed:15558019). Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.

Viewer

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding DYRK1B 0.43
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RANBP9 0.533
Publications: 1 Organism: Homo Sapiens