Summary

Name SCN2A
Full Name Sodium channel protein type 2 subunit alpha
Synonyms HBSC II, Sodium channel protein brain II subunit alpha, Sodium channel protein type II subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.2 | NAC2, SCN2A1, SCN2A2
Primary ID Q99250
Links - -
Type protein
Relations 33
Inhibitors phenytoin; lidocaine; carbamazepine; verapamil
Function Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient (PubMed:1325650, PubMed:17021166, PubMed:28256214, PubMed:29844171). Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation SCN2A 0.2
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SCN2A 0.2
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SCN2A 0.2
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation SCN2A 0.2
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SCN2A 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SCN2A 0.8
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png binding SCN2A 0.317
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN2A 0.279
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SCN2A 0.388
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SCN2A 0.275
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination SCN2A 0.324
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png phosphorylation SCN2A 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SCN2A 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN2A 0.276
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SCN2A 0.256
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition SCN2A 0.8
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN2A 0.276
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png chemical inhibition SCN2A 0.8
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN2A 0.339
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Action_potential 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SCN2A 0.262
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png chemical inhibition SCN2A 0.8
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/indirect-activation.png SCN2A 0.262
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCN2A 0.299
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png relocalization sodium(1+) 0.8
Publications: 1 Organism: Homo Sapiens