+ |
PRKCE | down-regulates activity
phosphorylation
|
GAD1 |
0.326 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-249264 |
Thr91 |
RDARFRRtETDFSNL |
in vitro |
|
pmid |
sentence |
15147202 |
We have identified one specific phosphorylation site, threonine 91 (T91), in hGAD67 that can be phosphorylated by PKA using MALDI-TOF. Site-directed mutation of T91 to alanine abolished PKA-mediated phosphorylation and inhibition of GAD activity. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
GAD1 | down-regulates quantity
chemical modification
|
L-glutamate(1-) |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267551 |
|
|
Homo sapiens |
|
pmid |
sentence |
32041144 |
Glutamate decarboxylase (GAD; EC 4.1.1.15) is a unique pyridoxal 5-phosphate (PLP)-dependent enzyme that specifically catalyzes the decarboxylation of L-glutamic acid to produce γ-aminobutyric acid (GABA), which exhibits several well-known physiological functions. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Aspartate and asparagine metabolism |
+ |
DNMT1 | down-regulates quantity by repression
transcriptional regulation
|
GAD1 |
0.36 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254574 |
|
|
Homo sapiens |
|
pmid |
sentence |
19029285 |
induction of the reelin and GAD67 mRNAs is accompanied by the dissociation of repressor complexes containing all three DNMTs, MeCP2, and HDAC1 from the corresponding promoters and by increased local histone acetylation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Rett syndrome |
+ |
HDAC1 | down-regulates quantity by repression
transcriptional regulation
|
GAD1 |
0.289 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254576 |
|
|
Homo sapiens |
|
pmid |
sentence |
19029285 |
induction of the reelin and GAD67 mRNAs is accompanied by the dissociation of repressor complexes containing all three DNMTs, MeCP2, and HDAC1 from the corresponding promoters and by increased local histone acetylation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
MECP2 | down-regulates quantity by repression
transcriptional regulation
|
GAD1 |
0.383 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254579 |
|
|
Homo sapiens |
|
pmid |
sentence |
19029285 |
induction of the reelin and GAD67 mRNAs is accompanied by the dissociation of repressor complexes containing all three DNMTs, MeCP2, and HDAC1 from the corresponding promoters and by increased local histone acetylation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Rett syndrome |
+ |
GAD1 | up-regulates quantity
chemical modification
|
gamma-aminobutyric acid |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-267552 |
|
|
Homo sapiens |
|
pmid |
sentence |
32041144 |
Glutamate decarboxylase (GAD; EC 4.1.1.15) is a unique pyridoxal 5-phosphate (PLP)-dependent enzyme that specifically catalyzes the decarboxylation of L-glutamic acid to produce γ-aminobutyric acid (GABA), which exhibits several well-known physiological functions. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Pathways: | Aspartate and asparagine metabolism |