Summary

Name TNKS2
Full Name Poly [ADP-ribose] polymerase tankyrase-2
Synonyms TANK2, ADP-ribosyltransferase diphtheria toxin-like 6, ARTD6, Poly [ADP-ribose] polymerase 5B, TNKS-2, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, Tankyrase II, Tankyrase-like protein, Tankyrase-related protein | PARP5B, TANK2, TNKL
Primary ID Q9H2K2
Links - -
Type protein
Relations 15
Inhibitors XAV939
Function Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:11739745, PubMed:11802774, PubMed:19759537, PubMed:21478859, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex

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Relations

Regulator Mechanism target score
+ down-regulates quantity img/direct_inhibition.png ubiquitination TNKS2 0.599
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ADP-ribosylation PSMF1 0.469
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ADP-ribosylation CASC3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png RNF146 0.599
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination, ADP-ribosylation AXIN1 0.693
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination AXIN2 0.682
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition TNKS2 0.8
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ADP-ribosylation TERF1 0.572
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png ADP-ribosylation AXIN2 0.682
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding TARDBP 0.2
Publications: 1 Organism: Rattus Norvegicus
Tissue: Brain
+ down-regulates activity img/direct_inhibition.png chemical inhibition TNKS2 0.8
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png GSK3B/Axin/APC 0.452
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ADP-ribosylation BLZF1 0.2
Publications: 1 Organism: Homo Sapiens