Summary

Name TAOK3
Full Name Serine/threonine-protein kinase TAO3
Synonyms Cutaneous T-cell lymphoma-associated antigen HD-CL-09, CTCL-associated antigen HD-CL-09, Dendritic cell-derived protein kinase, JNK/SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, Kinase from chicken homolog A, hKFC-A, Thousand and one amino acid protein 3 | DPK, JIK, KDS, MAP3K18
Primary ID Q9H2K8
Links - -
Type protein
Relations 5
Function Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation TAOK3 0.2
Publications: 2 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation STK3 0.295
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STK3/4 0.295
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation STK4 0.287
Publications: 1 Organism: Homo Sapiens