Summary

Name IKZF4
Full Name Zinc finger protein Eos
Synonyms Ikaros family zinc finger protein 4 | KIAA1782, ZNFN1A4
Primary ID Q9H2S9
Links - -
Type protein
Relations 1
Function DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation LNPEP 0.2
Publications: 1 Organism: Homo Sapiens