3.0
Summary
| Name |  TXNIP
|
| Full Name | Thioredoxin-interacting protein |
| Synonyms | Thioredoxin-binding protein 2, Vitamin D3 up-regulated protein 1 | VDUP1 |
| Primary ID | Q9H3M7 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). |
transcriptional regulation