Summary

Name GOLPH3
Full Name Golgi phosphoprotein 3
Synonyms Coat protein GPP34, Mitochondrial DNA absence factor, MIDAS | GPP34
Primary ID Q9H4A6
Links - -
Type protein
Relations 5
Function Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation GOLPH3 0.323
Publications: 2 Organism: In Vitro
+ up-regulates activity img/indirect-activation.png mTORC2 0.299
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png mTORC1 0.302
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png MTOR 0.34
Publications: 1 Organism: Homo Sapiens