Summary

Name DLL4
Full Name Delta-like protein 4
Synonyms Drosophila Delta homolog 4, Delta4
Primary ID Q9NR61
Links - -
Type protein
Relations 8
Pathways NOTCH Signaling
Function Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344).

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NRP1 0.374
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination DLL4 0.528
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ up-regulates activity img/direct-activation.png binding NOTCH1 0.624
Publications: 3 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation KDR 0.495
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation DLL4 0.494
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ up-regulates activity img/direct-activation.png binding PP2B 0.2
Publications: 1 Organism: Homo Sapiens