Summary

Name SIRT3
Full Name NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms hSIRT3, Regulatory protein SIR2 homolog 3, SIR2-like protein 3 | SIR2L3
Primary ID Q9NTG7
Links - -
Type protein
Relations 7
Function NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090). Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090). Important for regulating tissue-specific ATP levels (PubMed:18794531). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301). Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates quantity by stabilization img/direct-activation.png deacetylation CYP11A1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png deacetylation PDHA1 0.497
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png deacetylation IDH2 0.644
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation SIRT3 0.2
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png deacetylation SOD2 0.643
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SIRT3 0.414
Publications: 1 Organism: Homo Sapiens