Summary

Name EHF
Full Name ETS homologous factor
Synonyms hEHF, ETS domain-containing transcription factor, Epithelium-specific Ets transcription factor 3, ESE-3 | ESE3, ESE3B, ESEJ
Primary ID Q9NZC4
Links - -
Type protein
Relations 2
Function Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.

Viewer

Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DCDC2 0.269
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SPRR1B 0.242
Publications: 1