| + |
ARHGEF12 | up-regulates activity 
guanine nucleotide exchange factor
|
RHOA |
0.9 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260539 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32203420 |
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARHGEF12 | up-regulates
guanine nucleotide exchange factor
|
RHOA |
0.9 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84657 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 11094164 |
Here, we show that larg can activate rho in vivo |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNA13 | up-regulates activity
binding
|
ARHGEF12 |
0.764 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256519 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 12024019 |
P115 RhoGEF stimulates the intrinsic GTP hydrolysis activity of G alpha 12/13 subunits and acts as an effector for G13-coupled receptors by linking receptor activation to RhoA activation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GNAQ | up-regulates activity
binding
|
ARHGEF12 |
0.437 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256520 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 12024019 |
Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GNA12 | up-regulates activity
binding
|
ARHGEF12 |
0.757 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256522 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12024019 |
P115 RhoGEF stimulates the intrinsic GTP hydrolysis activity of G alpha 12/13 subunits and acts as an effector for G13-coupled receptors by linking receptor activation to RhoA activation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
ARHGEF12
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