| + |
KATNAL2 | down-regulates quantity by destabilization 
binding
|
TUBD1 |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267175 |
|
|
Mus musculus |
Testis |
| pmid |
sentence |
| 29136647 |
Here we show that KATNAL2 is critical for numerous aspects of this developmental process, including the initiation of the axoneme from the basal body, suppression of the spermatid centriole duplication cycle, sperm nuclear sculpting via the manchette, the attachment of the acrosome to the nucleus and the tethering of elongated spermatids to Sertoli cells via the tubulobulbar complex and ultimately sperm release via spermiation. KATNAL2 does not sever microtubules composed of α- and β-tubulin but does interact with δ- and ε-tubulin |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NUMA1 | up-regulates 
binding
|
TUBD1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-117159 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11956313 |
Direct binding of numa to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TUBD1 | up-regulates 
|
Microtubule_polimerization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267177 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28347630 |
Microtubules are essential for the generation, migration and differentiation of neurons. Within dendrites microtubules have also been implicated in the formation and plasticity of spines. For instance, the treatment of hippocampal neurons with low doses of the microtubule destabilizing drug Nocodazole impairs BDNF induced dendritic spine formation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
vincaleukoblastine sulfate | down-regulates activity
chemical inhibition
|
TUBD1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259257 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15579115 |
Tubulin binding molecules have generated considerable interest after the successful introduction of the taxanes into clinical oncology and the widespread use of the vinca alkaloids vincristine and vinblastine. These compounds inhibit cell mitosis by binding to the protein tubulin in the mitotic spindle and preventing polymerization into the MTs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TUBD1
- 
- 