Summary

Name RAB23
Full Name Ras-related protein Rab-23
Synonyms RAB23_HUMAN
Primary ID Q9ULC3
Links - -
Type protein
Relations 2
Function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.

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Relations

Regulator Mechanism target score
+ down-regulates img/indirect_inhibition.png GLIS2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png GLI3 0.562
Publications: 1 Organism: Homo Sapiens