Summary

Name AURKC
Full Name Aurora kinase C
Synonyms Aurora 3, Aurora/IPL1-related kinase 3, ARK-3, Aurora-related kinase 3, Aurora/IPL1/Eg2 protein 2, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase aurora-C | AIE2, AIK3, AIRK3, ARK3, STK13
Primary ID Q9UQB9
Links - -
Type protein
Relations 15
Inhibitors PHA-680632; ZM447439; N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide; 3-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-3-pyrazolyl]phenyl]-1,1-dimethylurea; AMG 900; N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide; SNS-314 Mesylate; CCT137690; CCT129202
Function Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ AURKCup-regulates activity img/direct-activation.png phosphorylation H3C1 0.2
Publications: 2 Organism: Homo Sapiens
+ AURKCup-regulates activity img/direct-activation.png phosphorylation TACC1 0.415
Publications: 1 Organism: In Vitro
+ PHA-680632down-regulates img/direct_inhibition.png chemical inhibition AURKC 0.8
Publications: 1 Organism: Homo Sapiens
+ ZM447439down-regulates img/direct_inhibition.png chemical inhibition AURKC 0.8
Publications: 1 Organism: Homo Sapiens
+ N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamidedown-regulates activity img/direct_inhibition.png chemical inhibition AURKC 0.8
Publications: 1 Organism: In Vitro
+ N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamidedown-regulates img/direct_inhibition.png chemical inhibition AURKC 0.8
Publications: 1 Organism: Homo Sapiens
+ 3-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-3-pyrazolyl]phenyl]-1,1-dimethylureadown-regulates img/direct_inhibition.png chemical inhibition AURKC 0.8
Publications: 1 Organism: Homo Sapiens
+ AMG 900down-regulates img/direct_inhibition.png chemical inhibition AURKC 0.8
Publications: 1 Organism: Homo Sapiens
+ N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamidedown-regulates img/direct_inhibition.png chemical inhibition AURKC 0.8
Publications: 1 Organism: Homo Sapiens
+ AURKCup-regulates img/direct-activation.png phosphorylation Histone H3 0.2
Publications: 1 Organism: Homo Sapiens
+ 3-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-3-pyrazolyl]phenyl]-1,1-dimethylureadown-regulates activity img/direct_inhibition.png chemical inhibition AURKC 0.8
Publications: 1 Organism: Homo Sapiens
+ SNS-314 Mesylatedown-regulates img/direct_inhibition.png chemical inhibition AURKC 0.8
Publications: 1 Organism: Homo Sapiens
+ CCT137690down-regulates img/direct_inhibition.png chemical inhibition AURKC 0.8
Publications: 1 Organism: Homo Sapiens
+ CCT129202down-regulates img/direct_inhibition.png chemical inhibition AURKC 0.8
Publications: 1 Organism: Homo Sapiens