| + |
TNF | up-regulates quantity by expression 
transcriptional regulation
|
JAG2 |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253608 |
|
|
Homo sapiens |
Rheumatoid Arthritis Disease Specific Synovial Fibroblast |
| pmid |
sentence |
| 14586405 |
We found that TNF induced the expression of Notch-1, Notch-4, and Jagged-2 in RSF. The expression of these proteins was detected in the RA synovial tissues. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAG2 | up-regulates 
binding
|
NOTCH1 |
0.603 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236922 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 9315665 |
Immunohistochemistry revealed coexpression of jagged2 and notch1 within thymus and other fetal murine tissues, consistent with interaction of the two proteins in vivo. Coculture of fibroblasts expressing human jagged2 with murine c2c12 myoblasts inhibited myogenic differentiation, accompanied by increased notch1 and the appearance of a novel 115-kda notch1 fragment. Exposure of c2c12 cells to jagged2 led to increased amounts of notch mrna as well as mrnas for a second notch receptor, notch3, and a second notch ligand, jagged1. Constitutively active forms of notchl in c2c12 cells also induced increased levels of the same set of mrnas, suggesting positive feedback control of these genes initiated by binding of jagged2 to notch1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | NOTCH Signaling |
| + |
JAG2 | up-regulates
binding
|
NOTCH3 |
0.603 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-82401 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11006133 |
These results suggest that delta1, jagged1, and jagged2 are ligands for notch1 and notch3 receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAG2 | up-regulates
binding
|
NOTCH2 |
0.614 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81367 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10958687 |
Binding of delta1, jagged1, and jagged2 to notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of notch2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAG2 | up-regulates
binding
|
NOTCH |
0.624 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269935 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10958687 |
Binding of delta1, jagged1, and jagged2 to notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of notch2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAG2 | up-regulates
|
JAG1 |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236888 |
|
|
Mus musculus |
C2C12 Cell, Myoblast |
| pmid |
sentence |
| 9315665 |
Immunohistochemistry revealed coexpression of jagged2 and notch1 within thymus and other fetal murine tissues, consistent with interaction of the two proteins in vivo. Coculture of fibroblasts expressing human jagged2 with murine c2c12 myoblasts inhibited myogenic differentiation, accompanied by increased notch1 and the appearance of a novel 115-kda notch1 fragment. Exposure of c2c12 cells to jagged2 led to increased amounts of notch mrna as well as mrnas for a second notch receptor, notch3, and a second notch ligand, jagged1. Constitutively active forms of notchl in c2c12 cells also induced increased levels of the same set of mrnas, suggesting positive feedback control of these genes initiated by binding of jagged2 to notch1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | NOTCH Signaling |
| + |
MIB2 | up-regulates
ubiquitination
|
JAG2 |
0.803 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137922 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15920166 |
Skeletrophin bound the intracellular regions of the notch ligand jagged-2, but not to those of delta-1, -3, -4, or jagged-1. Skeletrophin, but not its ring-mutated form, ubiquitinized the intracellular region of jagged-2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
JAG2
- 
- 