3.0
Summary
| Name |  DRG1View Modifications |
| Full Name | Developmentally-regulated GTP-binding protein 1 |
| Synonyms | DRG-1, Neural precursor cell expressed developmentally down-regulated protein 3, NEDD-3, Translation factor GTPase DRG1, TRAFAC GTPase DRG1, 3.6.5.- | NEDD3 |
| Primary ID | Q9Y295 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). |
phosphorylation