Summary

Name NR2E1
Full Name Nuclear receptor subfamily 2 group E member 1
Synonyms Nuclear receptor TLX, Protein tailless homolog, Tll, hTll | TLX
Primary ID Q9Y466
Links - -
Type protein
Relations 1
Function Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NR2E1 0.386
Publications: 1 Organism: Homo Sapiens