| + |
NFATC1 | up-regulates quantity by expression 
transcriptional regulation
|
GPC6 |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264022 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 21871017 |
NFAT transcriptionally regulates GPC6 induction in breast cancer cells and binds to three regulatory elements in the GPC6 proximal promoter. Expression of GPC6 in response to NFAT signalling promotes invasive migration, whereas GPC6 silencing with shRNA (small-hairpin RNA) potently blocks this phenotype. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GPC6 | up-regulates activity
binding
|
PTCH1 |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264031 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31756413 |
Based on results from in vitro experiments, we had previously proposed that GPC6 stimulates Hh signaling by interacting with Hh and Patched1 (Ptc1), and facilitating/stabilizing their interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFATC3 | up-regulates quantity by expression
transcriptional regulation
|
GPC6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264024 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 21871017 |
NFAT transcriptionally regulates GPC6 induction in breast cancer cells and binds to three regulatory elements in the GPC6 proximal promoter. Expression of GPC6 in response to NFAT signalling promotes invasive migration, whereas GPC6 silencing with shRNA (small-hairpin RNA) potently blocks this phenotype. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GPC6 | up-regulates activity
binding
|
SHH |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264029 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31756413 |
Based on results from in vitro experiments, we had previously proposed that GPC6 stimulates Hh signaling by interacting with Hh and Patched1 (Ptc1), and facilitating/stabilizing their interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFATC4 | up-regulates quantity by expression
transcriptional regulation
|
GPC6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264023 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 21871017 |
NFAT transcriptionally regulates GPC6 induction in breast cancer cells and binds to three regulatory elements in the GPC6 proximal promoter. Expression of GPC6 in response to NFAT signalling promotes invasive migration, whereas GPC6 silencing with shRNA (small-hairpin RNA) potently blocks this phenotype. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFATC2 | up-regulates quantity by expression
transcriptional regulation
|
GPC6 |
0.368 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264021 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 21871017 |
NFAT transcriptionally regulates GPC6 induction in breast cancer cells and binds to three regulatory elements in the GPC6 proximal promoter. Expression of GPC6 in response to NFAT signalling promotes invasive migration, whereas GPC6 silencing with shRNA (small-hairpin RNA) potently blocks this phenotype. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GPC6 | down-regulates activity 
binding
|
WNT5A |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264030 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 31756413 |
GPC6 binds to Wnt5a and inhibits its release from producing cells. Based on theseresults, and in our finding that GPC6 inhibits non-canonical Wnt signaling in the developing intestine,we tested the hypothesis that GPC6 binds to Wnt5aat the surface of the Wnt5a-producing mesenchymalcells and restrains its release from them. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GPC6
- 
- 