3.0
Summary
| Name |  MAD1L1View Modifications |
| Full Name | Mitotic spindle assembly checkpoint protein MAD1 |
| Synonyms | Mitotic arrest deficient 1-like protein 1, MAD1-like protein 1, Mitotic checkpoint MAD1 protein homolog, HsMAD1, hMAD1, Tax-binding protein 181 | MAD1, TXBP181 |
| Primary ID | Q9Y6D9 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PLK1 | up-regulates activity 
phosphorylation
|
MAD1L1 | 0.438 |
| Publications: | 1 | Organism: | In Vitro | |
| + | RPS6KA3 | up-regulates activity 
|
MAD1L1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAX | up-regulates activity
binding
|
MAD1L1 | 0.304 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TPR | up-regulates
binding
|
MAD1L1 | 0.499 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CENPE | up-regulates activity
|
MAD1L1 | 0.617 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | BUB1 | up-regulates activity
relocalization
|
MAD1L1 | 0.717 |
| Publications: | 1 | |||