| + |
PP2CA_R1A_R2A | down-regulates activity 
phosphorylation
|
DOCK6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275668 |
Ser1194 |
GQRSRLAsMLDSDTE |
|
|
| pmid |
sentence |
| 23462102 |
Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons|At later developmental stages, the abundance of the kinase Akt increased, resulting in the binding of Akt to Dock6 and the phosphorylation of Dock6 at Ser(1194). | In dorsal root ganglion neurons from mice lacking Dock6, reintroduction of Dock6 with a nonphosphorylatable S1194A mutation rescued axon extension but not branch number, whereas reintroduction of Dock6 with a phosphomimetic S1194E mutation resulted in premature branching |
|
| Publications: |
1 |
| + |
PP2CA_R1A_R2A | up-regulates activity 
dephosphorylation
|
PPME1 |
0.829 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265752 |
Ser15 |
MHLGRLPsRPPLPGS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24841198 |
The results subsequently revealed that phosphorylated PME-1/Ser15 is dephosphorylated by SIK2·PP2A (Fig. 5G). |Our results also demonstrated that the phosphorylated levels of PME-1/Ser15 and CaMKI/Thr177 are inversely correlated with the phosphatase activity of SIK2·PP2A complex, further implying that the demethylase activity of phosphorylated PME-1/Ser15 may be higher than that of its unphosphorylated state. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PP2CA_R1A_R2A | up-regulates activity
dephosphorylation
|
RAF1 |
0.54 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243534 |
Ser259 |
SQRQRSTsTPNVHMV |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16239230 |
... the PP2A holoenzymes ABC and ABC act downstream of Ras and upstream of MEK1 to promote activation of this MAPK signaling cascade. Furthermore both PP2A holoenzymes were found to associate with Raf1 and catalyze dephosphorylation of inhibitory phospho-Ser-259. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PP2CA_R1A_R2A | down-regulates activity
dephosphorylation
|
DCK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275804 |
Ser74 |
EFEELTMsQKNGGNV |
|
|
| pmid |
sentence |
| 24462681 |
Protein phosphatase 2A regulates deoxycytidine kinase activity via Ser-74 dephosphorylation|Deoxycytidine kinase (dCK) is a critical enzyme for activation of anticancer nucleoside analogs. Its activity is controlled via Ser-74 phosphorylation. Here, we investigated which Ser/Thr phosphatase dephosphorylates Ser-74. In cells, the PP1/PP2A inhibitor okadaic acid increased both dCK activity and Ser-74 phosphorylation |
|
| Publications: |
1 |
| + |
PP2CA_R1A_R2A | down-regulates activity
dephosphorylation
|
MASTL |
0.502 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276615 |
Thr194 |
NMMDILTtPSMAKPR |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 24391510 |
We demonstrate that PP2A/B55 is required for Gwl dephosphorylation at the essential Cdk site Thr194.Gwl phosphorylation by CycA/Cdk2 in vitro. Flag WT and Thr194A Gwl was transiently expressed and purified from asynchronous HEK 293T cells and incubated with recombinant CycA/Cdk2, following treatment with alkaline phosphatase (aPh) in the indicated samples. The proteins were analysed by immuno-blotting with anti-Gwl and Gwl pThr194 antibodies |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PP2CA_R1A_R2A | down-regulates activity
dephosphorylation
|
AKT1 |
0.689 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252613 |
Thr308 |
KDGATMKtFCGTPEY |
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 18042541 |
Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt.|Phosphorylation of Akt at regulatory residues Thr-308 and Ser-473 leads to its full activation. The protein phosphatase 2A (PP2A) has long been known to negatively regulate Akt activity. The PP2A holoenzyme consists of the structural subunit (A), catalytic subunit (C), and a variable regulatory subunit (B). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPP2CA | form complex 
binding
|
PP2CA_R1A_R2A |
0.937 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243424 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23454242 |
[PP2A] ... is multifarious as it is composed of catalytic, scaffold and regulatory subunits. The catalytic and scaffold subunits have two isoforms and the regulatory subunit has four different families containing different isoforms. The regulatory subunit is the most diverse with temporal and spatial specificity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R1A | form complex
binding
|
PP2CA_R1A_R2A |
0.926 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243427 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23454242 |
[PP2A] ... is multifarious as it is composed of catalytic, scaffold and regulatory subunits. The catalytic and scaffold subunits have two isoforms and the regulatory subunit has four different families containing different isoforms. The regulatory subunit is the most diverse with temporal and spatial specificity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP2R2A | form complex
binding
|
PP2CA_R1A_R2A |
0.904 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243430 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23454242 |
[PP2A] ... is multifarious as it is composed of catalytic, scaffold and regulatory subunits. The catalytic and scaffold subunits have two isoforms and the regulatory subunit has four different families containing different isoforms. The regulatory subunit is the most diverse with temporal and spatial specificity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PP2CA_R1A_R2A | down-regulates activity
dephosphorylation
|
AKT |
0.689 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243530 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 18042541 |
Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt.|Phosphorylation of Akt at regulatory residues Thr-308 and Ser-473 leads to its full activation. The protein phosphatase 2A (PP2A) has long been known to negatively regulate Akt activity. The PP2A holoenzyme consists of the structural subunit (A), catalytic subunit (C), and a variable regulatory subunit (B). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
4.0
PP2CA_R1A_R2A