| + |
CGRP receptor complex | up-regulates activity 
binding
|
GNAS |
0.423 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281423 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12196109 |
CGRP(1) receptors are represented by CRLR and RAMP1, and specific adrenomedullin receptors by CRLR and RAMP2 or 3. Here we discuss how CRLR/RAMP2 relates to adrenomedullin binding, pharmacology and pathophysiology, and how chemical cross-linking of receptor-ligand complexes in tissue relates to that in CRLR/RAMP2-expressing cells. CRLR, like other type II family G-protein-coupled receptors, signals via G(s) and adenylate cyclase activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAMP1 | form complex 
binding
|
CGRP receptor complex |
0.929 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281420 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24115156 |
Calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are related peptides that are potent vasodilators. The CGRP and AM receptors are heteromeric protein complexes comprised of a shared calcitonin receptor-like receptor (CLR) subunit and a variable receptor activity modifying protein (RAMP) subunit. RAMP1 enables CGRP binding whereas RAMP2 confers AM specificity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CALCRL | form complex
binding
|
CGRP receptor complex |
0.929 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281421 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24115156 |
Calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are related peptides that are potent vasodilators. The CGRP and AM receptors are heteromeric protein complexes comprised of a shared calcitonin receptor-like receptor (CLR) subunit and a variable receptor activity modifying protein (RAMP) subunit. RAMP1 enables CGRP binding whereas RAMP2 confers AM specificity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CALCA | up-regulates activity
binding
|
CGRP receptor complex |
0.809 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-281422 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24115156 |
Calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are related peptides that are potent vasodilators. The CGRP and AM receptors are heteromeric protein complexes comprised of a shared calcitonin receptor-like receptor (CLR) subunit and a variable receptor activity modifying protein (RAMP) subunit. RAMP1 enables CGRP binding whereas RAMP2 confers AM specificity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
CGRP receptor complex