SIGNOR_ID	COMPLEX_NAME	MEMBERS	COMPLEX_PORTAL_ID	DESCRIPTION
SIGNOR-C1	NFY	P25208;P23511;Q13952	CPX-1956
SIGNOR-C10	SMAD4/JUN	Q13485;P05412
SIGNOR-C100	ULK1/Atg13/Fip200	O75385;O75143;Q8TDY2		ULK1/Atg13/Fip200
SIGNOR-C101	TSC	Q92574;P49815	CPX-6142	TSC1/TSC2
SIGNOR-C102	SUZ12/EZH2/YY1	SIGNOR-C77;P25490		SUZ12/EZH2/YY1
SIGNOR-C103	NLI/Lmx1.1/Isl1 	Q9GZU7;Q8TE12;P61371		NLI/Lmx1.1/Isl1
SIGNOR-C104	RFX complex	O00287;O14593;P48382	CPX-6461	RFX complex
SIGNOR-C105	CoREST-HDAC complex	Q92769;O60341;O75362;Q9UKL0;Q13547		CoREST-HDAC complex
SIGNOR-C106	LMX1B/SFPQ/PSPC1 complex	O60663;P23246;Q8WXF1		LMX1B/SFPQ/PSPC1 complex
SIGNOR-C107	DNA-PK	P13010;P78527;P12956	CPX-3403	Ku70/Ku80/DNA-PK
SIGNOR-C108	NC2 complex	Q01658;Q14919		NC2 complex
SIGNOR-C109	ATG12/5/16L1	Q9H1Y0;O94817;Q676U5	CPX-200	ATG12/ATG5/ATG16L1
SIGNOR-C11	SMAD2/SMURF2	Q15796;Q9HAU4
SIGNOR-C110	GSK3B/Axin/APC	P49841;P25054;O15169		GSK3B/Axin/APC
SIGNOR-C111	REST-CoREST	Q9UKL0;Q13127		REST-CoREST
SIGNOR-C112	PARD6/SMURF1	Q9HCE7;Q9NPB6		PARD6/SMURF1
SIGNOR-C113	RAGAC	Q7L523;Q9HB90	CPX-2542	RAGAC
SIGNOR-C114	RAGAD	Q9NQL2;Q7L523	CPX-2513	RAGAD
SIGNOR-C115	RAGBC	Q5VZM2;Q9HB90	CPX-2514	RAGBC
SIGNOR-C116	RAGBD	Q5VZM2;Q9NQL2	CPX-767	RAGBD
SIGNOR-C117	AEP complex	Q9UHB7;P51825;SIGNOR-C238;Q03111		AEP complex
SIGNOR-C118	STAT1/STAT3	P40763;P42224	CPX-6041	STAT1/STAT3
SIGNOR-C119	Cullin4-RBX1-DDB1	Q96SW2;Q13619;Q16531;P62877	CPX-2759
SIGNOR-C12	SMAD7/HDAC1/E2F-1	Q13547;Q01094;O15105
SIGNOR-C120	JAK1/STAT1/STAT3	P23458;SIGNOR-C118		JAK1/STAT1/STAT3
SIGNOR-C121	PKCtheta/Nfix	Q04759;Q14938		PKCtheta/Nfix
SIGNOR-C122	Six1/Dach	Q15475;Q9UI36
SIGNOR-C123	MTA1/DJ1 complex 	Q13330;Q99497		MTA1/DJ1 complex
SIGNOR-C124	ISGF3 complex	Q00978;P42224;P52630	CPX-6016	ISGF3 complex
SIGNOR-C125	AHR-ARNT	P35869;P27540		AHR-ARNT
SIGNOR-C126	a7/b1 integrin	Q13683;P05556	CPX-1804	alpha7 beta1 integrin
SIGNOR-C127	MYOD/E12E47	P15172;P15923		MyoD homodimers or heterodimers of MyoD plus E12 or E47 serve as transcription factor complexes that bind to CANNTG consensus sites in the promoter regions of genes, performing major functions in specification and differentiation of skeletal muscle precursor cells
SIGNOR-C128	MYOD/HEB	Q99081;P15172		MYOD/HEB
SIGNOR-C129	MYOD/E2-2	P15172;P15884		MYOD/E2-2
SIGNOR-C13	NfKb-p65/p50	Q04206;P19838	CPX-5828
SIGNOR-C130	Polycomb repressive complex 2	O75530;Q6ZN18;Q09028;Q15910;Q15022		Polycomb repressive complex 2 (PRC2)
SIGNOR-C131	NAE	Q13564;Q8TBC4	CPX-2587	Nedd8-activating enzyme
SIGNOR-C132	PP2CA_R1A_R2A 	P30153;P63151;P67775		PP2Ca_R1A_Ba
SIGNOR-C133	PP2Ca_R1A_Bd  	P30153;P67775;Q00005		PP2Ca_R1A_Bd
SIGNOR-C134	PP2Ca_R1A_Bd	Q14738;P67775;P30153		PP2Ca_R1A_Bd
SIGNOR-C135	SCF-FBW7	P63208;Q13616;Q969H0		SCF-FBW7
SIGNOR-C136	SCF-SKP2	Q13616;P63208;Q13309		SCF-SKP2
SIGNOR-C137	GUCY1A2-B2	P33402;O75343		GUCY1A2-B2
SIGNOR-C138	GUCY1A2-B3	P33402;Q02153	CPX-2860	GUCY1A2-B3
SIGNOR-C139	GUCY1A3-B2	Q02108;O75343		GUCY1A3-B2
SIGNOR-C14	IKK-complex	O14920;Q9Y6K9;O15111	CPX-3269
SIGNOR-C140	GUCY1A3-B3	Q02108;Q02153	CPX-928	GUCY1A3-B3
SIGNOR-C142	IFNGR2/INFGR1	P38484;P15260		IFNGR2/INFGR1 complex
SIGNOR-C143	CyclinD1/CDK6	Q00534;P24385	CPX-2014
SIGNOR-C144	CDK5/CDK5R1	Q00535;Q15078	CPX-2201
SIGNOR-C146	ARP2/3	O15145;P59998;P61158;O15511;P61160;Q92747;O15144	CPX-2586	A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments.
SIGNOR-C147	MRE11/RAD50/NBS1	Q92878;O60934;P49959	CPX-4442	The mre11_rad50_nbs1 (mrn) complex is among the earliest respondents to dna double-strand break
SIGNOR-C149	hb:hp	SIGNOR-C209;P00738		The complex formation between Hp and Hb has been studied for decades and represents one of the strongest noncovalent interactions reported in plasma, with only some minor variations in binding strength of the Hp phenotypes (Hp1-1 > Hp2-1 > Hp2-2).After its release into plasma, Hb rapidly dissociates from the α2β2 tetrameric structure into αβ-dimers with the ability to bind Hp. The Hp region involved in binding these Hb (αβ)-units was recently shown by deletion analysis to include Hp1 β-chain residues 243 to 258.Hence, the Hp1-1 molecule is able to bind 2 Hb αβ-dimers (Figure 3), whereas the Hp2-1 and Hp2-2 may be able to bind several Hb αβ-dimers. Besides having a direct inhibitory effect on the toxic properties of Hb, as well as preventing peroxidative modification of Hb, Hp highly expedites Hb clearance, leading to production of anti-inflammatory metabolites.
SIGNOR-C15	AMPK	P54646;Q9Y478;P54619;Q9UGI9;Q9UGJ0;O43741;Q13131	CPX-5633
SIGNOR-C150	APC-c	Q9UJX3;Q9UJX6;Q13042;Q9UJX5;Q9BS18;P30260;Q9H1A4;Q9UJX2;Q9NYG5;Q8NHZ8;Q9UJX4;Q9UM13	CPX-1860	Anaphase promoting complex
SIGNOR-C151	Noncanonical PRC1	Q99496;Q6W2J9;P63208;Q9BSM1		 inhibition of adipogenesis does not require the JmjC demethylase domain of FBXL10, but it does require the F-box and leucine-rich repeat domains, which we show recruit a noncanonical polycomb repressive complex 1 (PRC1) containing RING1B, SKP1, PCGF1, and BCOR.
SIGNOR-C152	PAX2/TLE4	Q04727;Q02962		Recruitment of the groucho-related protein TLE4 may be involved in converting Pax2 into a transcriptional repressor
SIGNOR-C153	TCR	P01848;SIGNOR-C432;P01850	CPX-6581	The T-cell receptor, or TCR, is a molecule found on the surface of T cells, or T lymphocytes,[1] that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.
SIGNOR-C154	AP1	P01100;P05412	CPX-486	The structure of AP-1 is a heterodimer composed of proteins belonging to the c-Fos, c-Jun families
SIGNOR-C155	Calcineurin	P63098;Q08209		Calcineurin (CaN) is a calcium and calmodulin dependent serine/threonine protein phosphatase (also known as protein phosphatase 3, and calcium-dependent serine-threonine phosphatase)
SIGNOR-C156	PI3K	P27986;P42336	CPX-2384	Class I PI3K are heterodimeric molecules composed of a regulatory and a catalytic subunit
SIGNOR-C157	LE-TGN  SNARE	Q96AJ9;Q15836;O14662;O60499		Late endosomes- Trans Golgi Network soluble NSF attachment protein receptor (SNARE) complex
SIGNOR-C158	SMN complex	O14893;Q16637;Q9UHI6;Q8TEQ6;Q8WXD5;Q9H840;P57678	CPX-6031	Survival of motor neuron (SMN) complex
SIGNOR-C159	A1/b1 integrin	P05556;P56199	CPX-1798
SIGNOR-C16	CyclinE/CDK2	P24941;O96020	CPX-2016
SIGNOR-C160	A2/b1 integrin	P05556;P17301	CPX-1801
SIGNOR-C161	A3/b1 integrin	P05556;P26006	CPX-1797
SIGNOR-C162	A4/b1 integrin	P13612;P05556	CPX-1802
SIGNOR-C163	A5/b1 integrin	P05556;P08648	CPX-1794
SIGNOR-C164	A6/b1 integrin	P05556;P23229	CPX-1803
SIGNOR-C165	A8/b1 integrin	P53708;P05556	CPX-1815
SIGNOR-C166	A9/b1 integrin	P05556;Q13797	CPX-1816
SIGNOR-C167	A10/b1 integrin	O75578;P05556	CPX-1817
SIGNOR-C168	A11/b1 integrin	Q9UKX5;P05556	CPX-1818
SIGNOR-C169	AL/b2 integrin	P05107;P20701	CPX-1825
SIGNOR-C17	CyclinB/CDK1	P14635;P06493	CPX-2007
SIGNOR-C170	AM/b2 integrin	P05107;P11215	CPX-1826
SIGNOR-C171	AX/b2 integrin	P05107;P20702	CPX-1827
SIGNOR-C172	AD/b2 integrin	Q13349;P05107	CPX-1828
SIGNOR-C173	AIIB/b3 integrin	P08514;P05106	CPX-1799
SIGNOR-C174	A6/b4 integrin	P23229;P16144	CPX-1822
SIGNOR-C175	Av/b1 integrin	P06756;P05556	CPX-1819
SIGNOR-C176	Av/b2 integrin	P06756;P05107
SIGNOR-C177	Av/b3 integrin	P05106;P06756	CPX-1795
SIGNOR-C178	Av/b5 integrin	P06756;P18084	CPX-1796
SIGNOR-C179	Av/b6 integrin	P06756;P18564	CPX-1820
SIGNOR-C18	CyclinD/CDK4	P11802;P24385	CPX-2010
SIGNOR-C180	Laminin-9	Q16363;P55268;P11047	CPX-1778
SIGNOR-C181	Laminin-8	Q16363;P07942;P11047	CPX-1777
SIGNOR-C182	Laminin-10	O15230;P11047;P07942	CPX-1779
SIGNOR-C183	Laminin-1	P25391;P07942;P11047	CPX-1770
SIGNOR-C184	Laminin-5	Q13751;Q16787;Q13753
SIGNOR-C185	Av/b8 integrin	P26012;P06756	CPX-1821
SIGNOR-C186	AE/b7 integrin	P38570;P26010	CPX-1824
SIGNOR-C187	A4/b7 integrin	P26010;P13612	CPX-1823
SIGNOR-C189	SETDB1/NLK/CHD7	Q15047;Q9P2D1;Q9UBE8
SIGNOR-C19	HMT	P61964;O14686;Q9UBL3
SIGNOR-C190	PAS complex	Q92562;Q08AM6;Q9Y2I7		Sac3 assembles with PIKfyve and ArPIKfyve in a stable ternary complex and controls PtdIns(3,5)P2 levels
SIGNOR-C191	WRC complex	Q92558;Q9Y2A7;Q7L576;Q8WUW1;Q8IZP0		WAVE proteins are constitutively associated with four additional proteins in cells: Sra1/Cyfip1, Nap1/Hem-2, Abi and HSPC300. The components of this ~400 kDa pentamer, termed the WAVE regulatory complex (WRC) have all been implicated in control of Arp2/3 complex-mediated actin assembly in a wide range of systems.
SIGNOR-C192	GATOR1	Q12980;Q8WTW4;O75140	CPX-6226	Inhibition of GATOR1 subunits (DEPDC5, Nprl2, and Nprl3) makes mTORC1 signaling resistant to amino acid deprivation.
SIGNOR-C193	GATOR2	Q96S15;Q6PJI9;P55735;Q96EE3;Q9NXC5	CPX-6227	Inhibition of GATOR2 subunits (Mios, WDR24, WDR59, Seh1L, and Sec13) suppresses mTORC1 signaling, and epistasis analysis shows that GATOR2 negatively regulates DEPDC5
SIGNOR-C195	CLOCK/BMAL1	O15516;O00327	CPX-3229
SIGNOR-C196	CLOCK/BMAL2	O15516;Q8WYA1	CPX-3230
SIGNOR-C197	CBFA2T3/ZNF651	O75081;Q9UFB7		Heterodimeric transcription factor
SIGNOR-C198	SNAIL/RELA/PARP1	P09874;Q04206;O95863		The endogenous proteins PARP1, p65NF-κB and Snail1 form a ternary complex in the nuclei of cells that are actively expressing fibronectin
SIGNOR-C199	FCER1G/FCER1G	P30273
SIGNOR-C2	mTORC2	Q8TB45;P68104;P42345;Q9BVC4;P85299;Q6R327		mTORC2
SIGNOR-C200	FCER1	P12319;Q01362
SIGNOR-C202	GNB/GNG	P62873;P59768		GNB1/GNG2
SIGNOR-C203	SMAD2/STAT3/EP300	Q09472;Q15796;P40763		SMAD2/STAT3/EP300
SIGNOR-C204	SMAD3/PIAS3	P84022;Q9Y6X2		SMAD3/PIAS3
SIGNOR-C205	SMAD5/SMAD4	Q13485;Q99717
SIGNOR-C206	SMAD8/SMAD4	Q13485;O15198
SIGNOR-C207	Neurofilament L/M	P07197;P07196		Neurofilaments are obligate heteropolymers that are minimally comprised of the low molecular neurofilament protein L (NFL) plus the medium and/or high molecular weight proteins neurofilament protein M (NFM) and neurofilament protein H
SIGNOR-C208	Neurofilament L/H	P12036;P07196		Neurofilaments are obligate heteropolymers that are minimally comprised of the low molecular neurofilament protein L (NFL) plus the medium and/or high molecular weight proteins neurofilament protein M (NFM) and neurofilament protein H
SIGNOR-C209	Hemoglobin	P68871;P69905	CPX-2158
SIGNOR-C21	CDON/SPAG9	Q4KMG0;O60271
SIGNOR-C210	FN1/SDC4	P02751;P31431		FN1/SDC4
SIGNOR-C211	RUNX2/EP300	Q13950;Q09472		In osteoblastic cells expressing OC, p300 and RUNX2/Cbfa1 are components of the same nuclear protein complex
SIGNOR-C212	CSF2RA/CSF2RB	P32927;P15509		Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.
SIGNOR-C214	 Core Binding Factor complex	Q13951;Q01196		 The core binding factor (CBF) transcription complex, consisting of the interacting proteins RUNX1 and CBFβ, is essential for normal hematopoiesis
SIGNOR-C215	SMAD1/5/8/SMAD4	Q13485;SIGNOR-PF35		COMPLEX FORMED BY SMAD1/5/8 FAMILY AND SMAD4
SIGNOR-C216	FZD7/SDC4	O75084;P31431		FZD7/SDC4 complex
SIGNOR-C217	DGC	Q9Y4J8;Q9NSN8;P11532;Q13884;Q16586;Q13424;O60941;Q9NY99;Q13425;P24043;Q13326;Q14118;Q16585;P56539;Q92629;P29475		The Dystrophin Glycoprotein Complex (DGC) is composed of dystrophin, an elongated cytoskeletal protein that links to cytoplasmic gamma-actin and the transmembrane components of the DGC.
SIGNOR-C218	MAPK12/CARM1	Q86X55;P53778		P38gamma-CARM1 complex
SIGNOR-C219	LPR5/6	O75581;O75197		Low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) are co-receptors for Wnt ligands
SIGNOR-C220	Caspase 1 complex	P29466	CPX-952	Heterotetramer consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit.
SIGNOR-C221	Caspase 3 complex	P42574	CPX-970	Tetramer composed by two p17 and two p12 Caspase-3 subunits.
SIGNOR-C222	AIM2 inflammasome	O14862;Q9ULZ3;P29466	CPX-4142
SIGNOR-C223	NLRC4 inflammasome	P29466;Q9ULZ3;Q13075;Q9NPP4	CPX-4144
SIGNOR-C224	NLRP1 inflammasome	P29466;Q9C000;Q9ULZ3	CPX-4082
SIGNOR-C225	NLRP3 inflammasome	Q96P20;Q9ULZ3;P29466	CPX-4141
SIGNOR-C226	Pyrin inflammasome	Q9ULZ3;O15553;P29466	CPX-4143
SIGNOR-C227	Caspase 2 complex	P42575	CPX-969	Caspase-2 consists of anti-parallel arranged heterodimers of p12/p18 subunits.
SIGNOR-C228	Caspase 6 complex	P55212	CPX-971	Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit.
SIGNOR-C229	Caspase 9 complex	P55211	CPX-991	Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 35 kDa (p35) and a 10 kDa (p10) subunit. of Caspase-9.
SIGNOR-C23	TAF3/TRF3	Q6SJ96;Q5VWG9
SIGNOR-C230	Apoptosome	O14727;P55211;P99999	CPX-3762
SIGNOR-C231	Caspase 8 complex	Q14790	CPX-975	Tetramer composed by Caspase-8 p18 and p10 subunits.
SIGNOR-C232	Caspase 7 complex	P55210	CPX-2862	Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit of Caspase-7.
SIGNOR-C233	Ribonucleotide reductase	P23921;P31350	CPX-2194	Ribonucleotide reductase (RR) is responsible for the de novo conversion of the ribonucleoside diphosphates to deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair.RR consists of two subunits, hRRM1 and hRRM2.(pmid:14583450)
SIGNOR-C234	CyclinD3/CDK6	Q00534;P30281	CPX-2013	Cyclin-dependent protein kinase complex
SIGNOR-C238	P-TEFb	O60563;P50750	CPX-222	PMID: 20618343 The positive transcription elongation factor b (P-TEFb) composed of CDK9 and cyclin T1 stimulates gene expression by enhancing RNA polymerase II (RNA pol II) processivity.
SIGNOR-C24	DCX DET1-COP1	Q16531;Q8NHY2;Q7L5Y6;P62877;Q13619
SIGNOR-C240	Spike protein-ACE2	Q9BYF1;P59594	CPX-5683
SIGNOR-C241	Vps34 Complex II	Q99570;Q14457;Q8NEB9;Q9P2Y5	CPX-74
SIGNOR-C242	Vps34 Complex I	Q6ZNE5;Q99570;Q8NEB9;Q14457	CPX-73
SIGNOR-C243	IFNAR	P48551;P17181
SIGNOR-C244	STC2/HMOX1	O76061;P09601		Stanniocalcin 2, forms a complex with heme oxygenase 1 (stressosome), binds hemin and is a heat shock protein.|Taken together, our findings point to three novel functions of STC2, and suggest that STC2 interacts with HO1 to form a eukaryotic 'stressosome' involved in the degradation of heme.
SIGNOR-C245	AP-2 complex	Q96CW1;P53680;O94973;P63010	CPX-5150	Adaptor complex
SIGNOR-C246	Early Endosome	Q9UL25;P20338;P20339;Q15075;Q9H1K0;P61026;P61106;Q9UL26;CHEBI:17283
SIGNOR-C247	AP-3 complex	O00203;Q92572;Q9Y2T2;O14617	CPX-5051
SIGNOR-C248	AP-1 complex	P61966;O43747;Q10567;Q9BXS5	CPX-5047
SIGNOR-C249	AP-2/clathrin vescicle	P09496;P53675;SIGNOR-C245;CHEBI:18348;Q00610;P09497	SIGNOR-C245
SIGNOR-C25	NKX3-1/SRF	P11831;Q99801
SIGNOR-C250	AP-3/clathrin vescicle	P09496;P53675;Q00610;P09497;SIGNOR-C445;CHEBI:18348;SIGNOR-C247
SIGNOR-C251	AP-1/clathrin vescicle	Q00610;P09496;CHEBI:17526;SIGNOR-C248;P09497;P53675
SIGNOR-C252	BLOC-2	Q86YV9;Q969F9;Q9UPZ3	CPX-5044
SIGNOR-C253	BLOC-3	Q9NQG7;Q92902	CPX-5043
SIGNOR-C254	CoV2 Spike protein-ACE2	P0DTC2;Q9BYF1
SIGNOR-C255	Exosome_Complex	Q96B26;Q9NQT5;Q13868;Q06265;Q9NQT4;Q8TF46;CHEBI:18420;Q01780;Q15024;Q5RKV6;Q9NPD3;Q9Y3B2	CPX-600
SIGNOR-C256	EIF4E2/GIGYF1 complex	O60573;O75420
SIGNOR-C257	EIF4E2/GIGYF2 complex	O60573;Q6Y7W6
SIGNOR-C258	WASH complex	A8K0Z3;Q9Y3C0;Q9Y4E1;Q12768;Q2M389	CPX-1163
SIGNOR-C259	 p62_complex	Q7Z3B4;P37198;Q9BVL2		Thus, the p62-p58-p54 complex defines a group of proteins with strong protein-protein interactions that form a unit of pore structure essential for pore function. PMID:2050741
SIGNOR-C26	LAMTOR	Q0VGL1;O43504;Q6IAA8;Q9Y2Q5;Q9UHA4	CPX-4741
SIGNOR-C260	IL17R complex	Q8NAC3;Q96F46
SIGNOR-C261	DNA primase complex	P49642;P49643	CPX-2087
SIGNOR-C262	DNA polymerase alpha:primase complex	SIGNOR-C261;P09884;Q14181	CPX-2087
SIGNOR-C263	NPC	Q5SRE5;Q8NFH4;Q8WYP5;Q8NFH3;Q8WUM0;Q9BW27;Q12769;P57740;Q8NFH5;Q8TEM1;Q96HA1;Q53GS7;Q9BVL2;Q7Z3B4;P37198;P78406;Q92621;O15504;P49790;P49792;P12270;Q96EE3;P35658;P52948;Q9UKX7;Q9BTX1;Q99567;P55735;Q9NRG9;Q8N1F7;O75694	CPX-873
SIGNOR-C264	ATP synthase	P06576;P24539;O75947;Q9UII2;P18859;P25705;P30049;P48047;P05496;P36542;P03928;P56385;O75964	CPX-6151	Human mitochondrial ATP synthase, or complex V, consists of two functional domains, F1 and Fo. F1 comprises 5 different subunits (three α, three β, and one γ, δ and ε) and is situated in the mitochondrial matrix. Fo contains subunits c, a, b, d, F6, OSCP and the accessory subunits e, f, g and A6L.
SIGNOR-C265	Integrator complex	Q96HW7;Q9H0H0;Q96SY0;Q6P9B9;Q9NVH2;Q96CB8;Q9NV88;Q9NVM9;Q8N201;Q68E01;Q5TA45;Q9UL03;Q9NVR2;Q75QN2	CPX-6441
SIGNOR-C266	28S mitochondrial small ribosomal subunit	Q96EL2;P82921;Q9Y399;Q9Y3D5;Q9Y2R5;P82673;Q96BP2;Q9NWT8;P82664;O15235;O60783;P82914;Q9Y3D3;P82930;Q9Y291;Q92665;Q92552;Q9BYN8;P82663;Q9Y676;Q9Y2Q9;Q9Y3D9;P82650;P82932;P82912;Q9Y2R9;P51398;Q96EY7;P82933;P82675	CPX-5225	Component of the ribosome, the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). Responsible for the catalytic activity of the ribosome, the peptidyltransferase activity required to catalyze peptide bond formation. The mitochondrial ribosome (mitoribosome) is responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain.
SIGNOR-C267	CoV2 spike protein-NRP1	O14786;P0DTC2
SIGNOR-C268	MCM	P25205;P33992;P49736;P33991;P33993;Q14566	CPX-2940	The minichromosome maintenance protein complex (MCM) is a DNA helicase essential for genomic DNA replication
SIGNOR-C269	CHEVI complex	Q9H267;Q9H9C1	CPX-6241
SIGNOR-C27	AMOT/MPP5/INADL/LIN7C	Q8NI35;Q8N3R9;Q9NUP9
SIGNOR-C270	GPIb-IX-V complex	P40197;P14770;P13224;P07359	CPX-114
SIGNOR-C271	WAVE complex	Q9Y2A7;Q7L576;Q8IZP0;Q8WUW1;Q9Y6W5
SIGNOR-C272	STX11-SNAP23 SNARE complex	O75558;O00161
SIGNOR-C273	STX11-VAMP8 SNARE complex	Q15833;O75558;Q9BV40
SIGNOR-C274	KATP channel	Q14654;Q15842;O60706;Q09428
SIGNOR-C275	VAPB-PTPIP51 complex	O95292;Q96TC7		ER-mitochondrion tethering complex
SIGNOR-C276	Mitochondrial Fe-S Cluster Assembly Complex	Q9H1K1;Q9Y697;Q16595;Q9HD34	CPX-5641	Required for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins
SIGNOR-C277	Mitochondrial respiratory chain complex I	P03905;O43181;P03901;P03915;P03897;Q9P0J0;O43678;O43676;P03891;P03886;O75251;P03923;P49821;O15239;P19404;O95299;O75489;Q9Y6M9;P28331;O95169;Q16795;O75306;O75380;O00217;Q9NX14;P17568;Q86Y39;Q9UI09;P56181;O43920;P51970;O95168;Q16718;O95139;O95182;O75438;O43677;O96000;P56556;O14561;O43674;O95178;O95167;O95298	CPX-577	Catalyses the first step of electron transport by the oxidation of NADH, thus providing two electrons for the reduction of ubiquinone.
SIGNOR-C278	Mitochondrial respiratory chain complex II	Q99643;P21912;P31040;O14521	CPX-561	Accepts electrons from electron carriers reduced in glycolysis and the tricarboxylic acid cycle.
SIGNOR-C279	Mitochondrial respiratory chain complex III	P47985;O14949;P07919;P00156;Q9UDW1;P31930;P08574;P22695;O14957;P14927	CPX-560
SIGNOR-C280	Mitochondrial respiratory chain complex IV	P14406;P13073;P00414;P14854;P15954;P24311;P10606;P00403;P12074;P00395;P10176;O00483;P20674;P09669	CPX-6123
SIGNOR-C281	HAUS complex	Q9BT25;Q96CS2;Q99871;Q7Z4H7;Q68CZ6;Q9NVX0;Q9H6D7;O94927	CPX-1847
SIGNOR-C282	g-TuRC complex	Q96CW5;Q96RT7;Q9BSJ2;Q9UGJ1;Q96RT8
SIGNOR-C285	39S mitochondrial large ribosomal subunit	P49406;Q9NVS2;Q7Z7F7;Q6P161;Q4U2R6;Q8N5N7;Q9BYC8;Q9NRX2;Q9BQC6;Q9NP92;Q14197;Q96EL3;Q96GC5;Q9H2W6;Q9H9J2;Q9Y6G3;Q8IXM3;Q9NQ50;Q9BYD3;Q96DV4;Q9P0J6;Q9NZE8;Q9BQ48;O75394;Q8TCC3;P09001;Q13084;Q9P0M9;Q96A35;Q16540;Q9NWU5;Q7Z2W9;Q9BYC9;Q5T653;Q9H0U6;Q9NX20;Q9P015;Q6P1L8;P52815;Q9Y3B7;Q7Z7H8;Q9BYD6;Q8TAE8;Q86TS9;Q9HD33;Q9BRJ2;Q8N983;Q9BYD1;Q9BZE1;Q9BYD2;Q9NYK5;Q13405	CPX-5226
SIGNOR-C286	40S cytosolic small ribosomal subunit	P62847;P46782;P62241;P62854;P62753;P62273;P60866;P62857;P08865;P39019;P46781;P63220;P22090;Q8TD47;P23396;P62701;P62263;P15880;P62081;P62841;P46783;P62861;P62280;P25398;P62277;P62244;P62249;P08708;P62269;P62266;P62851;P42677;Q71UM5;P62979;P61247	CPX-5223
SIGNOR-C287	60S cytosolic large ribosomal subunit	P05386;P63173;P35268;P62899;P30050;P50914;P27635;P46778;P18621;P62987;Q96L21;Q9UNX3;Q969Q0;P83881;Q96EH5;P62891;P62906;Q02543;P84098;P62829;P83731;P61353;P47914;P62888;P62910;P49207;P42766;Q9Y3U8;P61927;P36578;P62945;P18124;P62424;P62917;P32969;P05388;P61254;P61313;Q6P5R6;P46779;Q92901;P26373;P62913;P18077;P39023;P05387;P61513;P46776;P46777;Q02878;Q07020;P40429;P62750	CPX-5183
SIGNOR-C288	BBsome complex	Q8IWZ6;Q8N3I7;Q8TAM2;Q3SYG4;Q9BXC9;Q8NFJ9;Q96RK4;A8MTZ0	CPX-1908
SIGNOR-C289	DPM complex	Q9P2X0;O94777;O60762	CPX-6268	 dolichyl beta-D-mannosyl phosphate synthase complex
SIGNOR-C29	BMPR1A/1B/2	P36894;Q13873;O00238
SIGNOR-C290	Hair cells mechanotransduction channel	Q92508;Q8TDI7;Q8TDI8;Q9H5I5
SIGNOR-C291	TIP-LINK complex	Q9Y6N9;Q495M9;Q96QU1;Q13402;Q9H251
SIGNOR-C292	Caspase-2 PIDDosome	P78560;Q9HB75;P42575	CPX-3905
SIGNOR-C293	Calprotectin complex	P06702;P05109	CPX-37	S100A9-S100A8 complex
SIGNOR-C294	SAE1/SAE2 complex	Q9UBE0;Q9UBT2	CPX-2161	SUMO activating enzyme complex
SIGNOR-C295	BRCC ubiquitin ligase complex	SIGNOR-C297;Q9NXR7;P51587;P46736;Q06609	CPX-955
SIGNOR-C296	BRCA1-A complex	Q96RL1;Q6UWZ7;Q9NXR7;Q9NWV8;P46736;SIGNOR-C297	CPX-4425
SIGNOR-C297	BRCA1-BARD1 complex	P38398;Q99728	CPX-715
SIGNOR-C298	BRCA1-B complex	Q9BX63;Q92547;SIGNOR-C297;CHEBI:49883	CPX-4426
SIGNOR-C299	BRCA1-C complex	Q99708;CHEBI:29035;CHEBI:4705;CHEBI:29105;SIGNOR-C147;SIGNOR-C297	CPX-4441
SIGNOR-C3	mTORC1	Q8N122;P42345;Q9BVC4;Q8TB45;Q96B36
SIGNOR-C30	ACVR1/BMPR2	Q04771;Q13873
SIGNOR-C300	Fanconi anemia core complex	Q00597;Q0VG06;Q9BTP7;O15287;O15360;Q9NPI8;Q9NW38;Q8NB91;Q8IYD8;Q9HB96	CPX-6263
SIGNOR-C301	D1-D2-G-X3 complex	O15287;Q9BXW9;P51587;O43542
SIGNOR-C302	Fanconi anemia ID complex	Q9NVI1;Q9BXW9	CPX-6264
SIGNOR-C303	LINC complex	Q9UH99;Q8NF91;Q8TAQ9;Q8N6L0;Q8N205;Q8TC36;O94901;Q6ZMZ3;Q9NPE6;Q8WXH0		A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis.
SIGNOR-C304	Cohesin complex	Q9UQE7;O60216;Q8WVM7;Q14683;SIGNOR-PF52	CPX-5989	Cohesin is an evolutionarily conserved complex composed of four core proteins (SMC1A, SMC3, RAD21 and either STAG2 or STAG1) that form a ring-shaped structure able to encircle chromatin
SIGNOR-C305	TTM complex	Q8NA31;Q8NHR7;Q3KP22		Also known as TERB1-TERB2-MAJIN, tethers telomeres to the nuclear envelope.
SIGNOR-C306	Shelterin complex	Q15554;Q9NYB0;Q9BSI4;SIGNOR-C64;P54274	CPX-152	The Shelterin (Telosome) complex is a DNA-binding protein complex that associates with and protects the telomeres.
SIGNOR-C307	26S Proteasome	P25789;P48556;Q9UNM6;P60896;O43242;P20618;P28074;P60900;P49721;Q13200;O14818;Q15008;P17980;P25788;O00232;Q99436;P28070;P25787;P62195;Q99460;P28066;P35998;P62191;P43686;P62333;P25786;P28072;P49720;O00231;P51665;P55036;O00487;Q16186	CPX-5993	Multi-enzyme complex that functions as the primary degradation machinery for the selective turnover of surplus or damaged proteins within the cell.
SIGNOR-C308	Complement C1q	P02746;P02747;P02745	CPX-1919
SIGNOR-C309	Complement C1 complex	SIGNOR-C308;P00736;P09871	CPX-1920
SIGNOR-C310	C3 convertase complex	P0C0L5;P0C0L4;P06681	CPX-6156	Also known as C4b2a, it is formed by the complement cleavage products C4b and C2a. It cleaves C3 into C3a and C3b.
SIGNOR-C311	Fibrinogen	P02671;P02679;P02675	CPX-1922
SIGNOR-C312	C5 convertase complex	SIGNOR-C310;P01024	CPX-6158	Also known as C4b2a3b, it is formed by the complement cleavage products C4b, C2a and C3b. It cleaves C5 into C5a and C5b.
SIGNOR-C313	Membrane attack complex	P13671;P01031;P07357;P10643;P07360;P02748;P07358	CPX-6159	Also known as MAC complex, it creates pores that disrupt the cell membrane of target cells, leading to cell lysis and death.
SIGNOR-C314	C3 convertase complex (C3bBb)	P00751;P01024	CPX-5601	Alternative complement pathway C3 convertase.
SIGNOR-C315	C5 convertase complex (C3bBbC3b)	P01024	CPX-5604	Alternative complement pathway C5 convertase.
SIGNOR-C316	Thrombin-Thrombomodulin	P07204;P00734	CPX-6223
SIGNOR-C317	Fibrin	SIGNOR-C311	CPX-6225	Fibrin monomer
SIGNOR-C318	Factor Va-Xa	P12259;P00742	CPX-6221
SIGNOR-C319	Factor FVIIa:TF	P13726;P08709	CPX-2808
SIGNOR-C32	RISC(DICER1/AGO2/TARBP2)	Q15633;Q9UPY3;Q9UKV8	CPX-134
SIGNOR-C320	Factor VIIIa-IXa	P00740;P00451	CPX-6204	Coagulation factor
SIGNOR-C321	CENP-A nucleosome	P49450;P06899;P62805;P04908	CPX-5647
SIGNOR-C322	Nucleosome_H2A.Z.1 variant	P68431;P0C0S5;P06899;P62805	CPX-5670
SIGNOR-C323	Nucleosome_H2A.Z.2 variant	P62805;P06899;Q71UI9;P68431	CPX-5671
SIGNOR-C324	Nucleosome_H3.1 variant	P62805;P06899;P68431;P04908;SIGNOR-PF70	CPX-2556
SIGNOR-C325	Nucleosome_H3.1t variant	Q16695;P62805;P06899;P04908	CPX-2564
SIGNOR-C326	GABA-A (a4-b2-d) receptor	O14764;P48169;P47870	CPX-2953
SIGNOR-C327	GABA-A (a4-b3-d) receptor	P48169;P28472;O14764	CPX-2954
SIGNOR-C328	GABA-A (a6-b2-d) receptor	P47870;Q16445;O14764	CPX-2952
SIGNOR-C329	GABA-A (a6-b3-d) receptor	P28472;O14764;Q16445	CPX-2951
SIGNOR-C33	CDX2/PAX6/P300	Q99626;P26367;Q09472
SIGNOR-C330	GABA-A (a1-b1-g2) receptor	P14867;P18507;P18505
SIGNOR-C331	GABA-A (a2-b1-g2) receptor	P18505;P47869;P18507
SIGNOR-C332	GABA-A (a3-b1-g2) receptor	P34903;P18505;P18507
SIGNOR-C333	GABA-A (a4-b1-g2) receptor	P48169;P18507;P18505
SIGNOR-C334	GABA-A (a6-b1-g2) receptor	P18505;P18507;Q16445
SIGNOR-C335	GABA-A (a5-b1-g2) receptor	P18507;P18505;P31644
SIGNOR-C336	GABA-B receptor	O75899;Q9UBS5	CPX-2955
SIGNOR-C337	MBD2/NuRD complex	Q8WXI9;Q86YP4;Q14839;Q92769;Q13547;Q09028;Q9BTC8;O94776;Q13330;Q9UBB5;Q12873;Q16576	CPX-880
SIGNOR-C338	MBD3/NuRD complex	Q8WXI9;O95983;Q92769;Q13547;Q9BTC8;O94776;Q13330;Q12873;Q09028;Q16576;Q86YP4;Q14839	CPX-922
SIGNOR-C339	Nucleosome_H3.3 variant	P06899;P84243;P62805;P04908
SIGNOR-C34	RNA helicases DDX5/DDX17	P17844;Q92841
SIGNOR-C340	CERF	Q9BXF3;P51531		Biochemical isolation of CECR2 revealed the presence of this protein as a component of a novel heterodimeric complex termed CECR2-containing remodeling factor (CERF). CERF comprises CECR2 and the ATP-dependent chromatin remodeler SNF2L, a mammalian ISWI ortholog expressed predominantly in the central nervous system.
SIGNOR-C341	Condensin I	Q15021;Q9NTJ3;O95347;Q15003;Q9BPX3	CPX-979
SIGNOR-C342	Condensin II	Q86XI2;P42695;Q6IBW4;O95347;Q9NTJ3	CPX-985
SIGNOR-C343	TFIID	P49848;Q15543;Q12962;Q7Z7C8;Q15545;Q15542;Q6P1X5;Q5VWG9;Q16594;Q15544;O00268;Q16514;P20226;P21675	CPX-915
SIGNOR-C344	MSL acetyltransferase	Q8N5Y2;Q9HCI7;Q68DK7;Q9H7Z6	CPX-815	Human histone acetyltransferase complex (hMSL) that contains homologs of the Drosophila dosage compensation proteins MOF, MSL1, MSL2, and MSL3. This complex shows strong specificity for histone H4 lysine 16 in chromatin in vitro, and RNA interference-mediated knockdown experiments reveal that it is responsible for the majority of H4 acetylation at lysine 16 in the cell. PMID: 16227571
SIGNOR-C345	SF3a	Q15428;Q15459;Q12874	CPX-2565
SIGNOR-C346	SNARE_complex 	P63027;P60880;Q16623
SIGNOR-C347	NMDA receptor_2A	Q05586;Q12879	CPX-2202
SIGNOR-C348	NMDA receptor_2B	Q13224;Q05586	CPX-285
SIGNOR-C349	NMDA receptor_2C	Q05586;Q14957	CPX-286
SIGNOR-C350	NMDA receptor_2D	O15399;Q05586	CPX-289
SIGNOR-C351	Synaptonemal_complex	Q8IZU3;Q15431;Q6PIF2;Q9BX26;Q8N0S2;A1L190;Q9BXU0
SIGNOR-C352	Set1-Ash2 HMT complex	Q9UBL3;O15047;P61964
SIGNOR-C353	BHC complex	Q13547;Q96BD5;Q9UKL0;O60341;Q92769;Q9P0W2
SIGNOR-C354	Lig4-Xrcc4 complex	Q13426;P49917	CPX-618
SIGNOR-C355	RAD21L Cohesin complex	Q9H4I0;Q9UJ98;Q14683;Q9UQE7	CPX-7441
SIGNOR-C356	Microprocessor complex	Q9NRR4;Q8WYQ5	CPX-3080	Microprocessor recognizes pri-miRNA through the stem- and the stem-loop-ssRNA junction, and cleaves both the 5′ and 3′ flanking segments to generate pre-miRNA.
SIGNOR-C357	RZZ complex	Q9H900;O95229;O43264;P50748	CPX-6017
SIGNOR-C358	NRZ complex	A2RRP1;O43264;Q6NUQ1	CPX-6201	Multisubunit tethering complex for retrograde trafficking of COPI vesicles from the Golgi to the endoplasmic reticulum.
SIGNOR-C360	MECP2/SIN3A/HDAC complex	Q13547;Q96ST3;Q92769;P51608
SIGNOR-C361	Ndc80 complex	Q9BZD4;Q8NBT2;Q9HBM1;O14777	CPX-550	Component of the KMN network.
SIGNOR-C362	MIS12 complex	Q6P1K2;Q9H081;Q96IY1;Q9H410	CPX-5643	Component of the KMN network
SIGNOR-C363	KNL1 complex	O95229;Q8NG31	CPX-5644	Component of the KMN network
SIGNOR-C364	SKA complex	Q8WVK7;Q96BD8;Q8IX90	CPX-5642	The Ska complex is an essential mitotic component required for accurate cell division in human cells
SIGNOR-C365	CCAN complex	Q96H22;A8MT69;Q03188;Q92674;Q9NSP4;Q9BU64;Q6IPU0;Q7L2Z9;Q8N2Z9;Q96BT3;Q8N0S6;Q9H3R5;Q71F23;Q5EE01;Q9BS16;Q13352	CPX-5646
SIGNOR-C366	KMN network	SIGNOR-C361;SIGNOR-C362;SIGNOR-C363		The 10-subunit KMN assembly (comprising KNL1, MIS12, and NDC80 complexes, designated KNL1C, MIS12C, and NDC80C) binds microtubules and regulates mitotic checkpoint function through NDC80C and KNL1C.
SIGNOR-C367	Upf-EJC	Q9HAU5;Q9BZI7;Q92900
SIGNOR-C368	SEC61 complex	P60468;P60059;Q9H9S3;P61619		 translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER)
SIGNOR-C369	Exon junction complex	O15234;P61326;P38919;Q9Y5S9	CPX-1941
SIGNOR-C37	CyclinK/CDK12	O75909;Q9NYV4	CPX-241
SIGNOR-C370	COPII vesicle	Q15436;O15027;O95486;P53992;O95487;O94855;Q15437;Q9NQW1;P55735;O94979		Coat protein complex (COP) II vesicles export newly synthesized secretory proteins from the endoplasmic reticulum (ER).
SIGNOR-C371	Nucleosome	P62805;SIGNOR-PF69;SIGNOR-PF68;SIGNOR-PF70
SIGNOR-C372	POMT 	Q9UKY4;Q9Y6A1	CPX-2659	Protein O-mannosyltransferase 1 (POMT1) and its homologue POMT2 are responsible for the catalysis of the first step in O-mannosyl glycan synthesis
SIGNOR-C373	Rix1 complex	Q8IZL8;Q9NXF1;Q9BV38;Q5SY16;Q9H4L4
SIGNOR-C374	SMC5/6 	Q8IY18;Q96SB8;Q96MG7;Q96MF7;Q8WV22;Q9NXX6	CPX-6086
SIGNOR-C375	RF-C complex	P35249;P35251;P40937;P35250;P40938	CPX-415	Replication factor C (RF-C) complex binds to DNA primers and loads PCNA onto DNA, thereby increasing the processivity of DNA polymerases.
SIGNOR-C376	DNA polymerase delta 	Q9HCU8;P28340;Q15054;P49005	CPX-2097	Believed to be the major polymerase for the elongation of both leading and lagging strands of chromosomal DNA in eukaryotic cells.
SIGNOR-C377	DNA polymerase epsilon	Q9NR33;Q9NRF9;Q07864;P56282	CPX-2108	Complex that plays a role in the elongation of both leading and lagging strands of chromosomal DNA in eukaryotic cells
SIGNOR-C378	DNA polymerase gamma	P54098;Q9UHN1	CPX-2093	Human mitochondrial DNA polymerase (Pol gamma) is the sole replicase in mitochondria.
SIGNOR-C379	ESCRT-III	Q9H444;Q7LBR1;Q8WUX9;Q96FZ7;Q9BY43;Q9HD42;Q9NZZ3;Q9UQN3;Q96CF2;O43633;Q9Y3E7	CPX-329
SIGNOR-C38	CyclinK/CDK13	Q14004;O75909	CPX-359
SIGNOR-C380	IPP complex	Q7Z4I7;Q9NVD7;P48059;P0CW19;P0CW20;Q13418		Integrin-linked kinase (ILK), and isoforms of particularly interesting Cys-His-rich protein (PINCH) and parvin form the IPP complex. In the cytoplasm, and this complex is recruited to focal adhesions.
SIGNOR-C381	BLOC-1	O95295;Q6QNY1;Q9UL45;P78537;Q9NUP1;Q96EV8;Q6QNY0;Q8TDH9	CPX-1910	Lysosome-related organelles complex-1 (BLOC-1).
SIGNOR-C382	MCC	O43684;O60566;Q12834;Q13257	CPX-3946	Mitotic Checkpoint Complex
SIGNOR-C383	Ankyrin complex	P16452;Q08722;P11166;Q14773;P06028;Q02094;P18577;P16157;P02724;P02730		Junctional complex required to maintain red blood cell mechanical integrity and stability.
SIGNOR-C384	Erythrocytic spectrin	P11277;P02549	CPX-2499	Heterodimer of erythrocytic alpha and beta spectrins.
SIGNOR-C385	Non-erythrocytic spectrin	SIGNOR-PF73;Q13813		Heterodimer of non-erythrocytic alpha and beta spectrins.
SIGNOR-C386	4.1 complex	P02730;P11166;P04921;P11171;P35611;P35612;P27105		Junctional complex required to maintain red blood cell mechanical integrity and stability.
SIGNOR-C387	CFII complex	O94913;Q92989		Cleavage factor II (CF II) is a heterodimer of PCF11 and CLP1 catalyzing 3′ cleavage and polyadenylation of mammalian mRNA precursors.
SIGNOR-C388	CFI complex	Q8N684;O43809;Q16630		Cleavage factor I (CF I) complex, involved in one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors.
SIGNOR-C389	RNA Polymerase III	P62875;P19388;O15160;O14802;Q9Y535;O15318;Q9H1D9;Q9NVU0;P05423;Q9BUI4;O75575;P0DPB6;P52434;P53803;Q9NW08;Q9Y2Y1;P61218	CPX-2393	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.It synthesizes small RNAs, such as snRNA and tRNAs.
SIGNOR-C39	DDB2/DDB1	Q92466;Q16531	CPX-308
SIGNOR-C390	RNA Polymerase I	P0DPB5;P62875;P61218;P0DPB6;P52434;P53803;O95602;Q9GZS1;Q9H9Y6;O15446;Q3B726;Q9P1U0;O15160;P19388	CPX-2386	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It synthesizes rRNAs.
SIGNOR-C391	RNA Polymerase II	P24928;P19388;P52435;P52434;Q6EEV4;P53803;P30876;P19387;O15514;P62487;P36954;P0CAP2;P61218;P62875;Q9H1A7;Q9GZM3	CPX-7481	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It synthesizes mRNAs.
SIGNOR-C392	TFIIIC	Q9Y5Q9;Q12789;Q969F1;Q9Y5Q8;Q9UKN8;Q8WUA4	CPX-2373	Required for RNA polymerase III-mediated transcription.
SIGNOR-C393	TFIIIB	Q92994;A6H8Y1;Q9HAW0;P20226		Required for RNA polymerase III-mediated transcription.
SIGNOR-C394	TFIIF	P13984;P35269	CPX-79	TFIIF is a general transcription initiation factor that binds to RNA polymerase II.
SIGNOR-C395	TFIIA	P52657;P52655	CPX-519	TFIIA is a general transcription initiation factor that binds to RNA polymerase II.
SIGNOR-C396	IDH	P51553;P50213;O43837	CPX-553	Tricarboxylic acid cycle enzyme which catalyzes the conversion of threo-Ds-isocitrate to alpha-ketoglutarate and carbon dioxide, important for regulatory control of mitochondrial energy metabolism.
SIGNOR-C397	OGDC	Q02218;Q9ULD0;P36957;P09622		Oxoglutarate dehydrogenase complex
SIGNOR-C398	Succinyl-CoA  ATP variant	P53597;Q9P2R7	CPX-6176	Mitochondrial succinyl-CoA synthetase complex, ATP-specific variant
SIGNOR-C399	Succinyl-CoA  GTP variant	Q96I99;P53597	CPX-6175
SIGNOR-C400	SDH	P31040;CHEBI:21137;CHEBI:49601;Q99643;CHEBI:49883;P21912;O14521	CPX-561	Mitochondrial respiratory chain complex II
SIGNOR-C401	EIF3_complex	O15371;O75821;Q7L2H7;Q9Y262;Q9UBQ5;O75822;Q13347;Q14152;O15372;P60228;O00303;P55884;Q99613	CPX-6036
SIGNOR-C402	PDH	O00330;P11177;P08559;P29803;P09622;P10515	CPX-6233
SIGNOR-C403	EBV gH:gL:gp42	P03205;P03212;P03231		Infection of B lymphocytes by Epstein-Barr virus (EBV) requires attachment of virus via binding of viral glycoprotein gp350 to CD21 on the cell surface. Penetration of the cell membrane additionally involves a complex of three glycoproteins, gH, gL, and gp42. Glycoprotein gp42 binds to HLA-DR. PMID: 9151859
SIGNOR-C405	Core mediator complex	Q9NVC6;Q15648;O60244;Q9NPJ6;Q96HR3;Q9H204;Q9NWA0;Q9H944;Q13503;O75586;Q9BUE0;Q9P086;Q9Y3C7;Q9ULK4;Q9BTT4;O43513;Q96G25;Q9NX70;O95402;A0JLT2;Q6P2C8;Q96RN5;Q15528;Q9Y2X0;Q71SY5;O75448	CPX-3227
SIGNOR-C406	CKM complex	P49336;Q9UHV7;Q93074;P24863;Q71F56	CPX-3232	Also known as CDK8 module.
SIGNOR-C407	ChAHP	Q14839;Q9H2P0;Q13185;P83916		ChAHP, a gene-regulatory complex that consists of the chromatin remodeller CHD4, the DNA-binding factor ADNP, and the heterochromatin proteins HP1β and HP1γ.
SIGNOR-C408	Polycomb repressive complex 1	Q8IXK0;P78364;Q99496;P35226;P35227;Q14781		Polycomb repressive complex 1 (PRC1)
SIGNOR-C409	Sin3B_complex	Q96QT6;Q9UBU8;Q13547;O75182
SIGNOR-C41	DICER1/hAgo2/PRKRA	O75569;Q9UPY3;Q9UKV8	CPX-1072
SIGNOR-C410	Outer_mitochondrial_membrane	CHEBI:64482;CHEBI:16038;CHEBI:28874		The outer lipid bilayer of the mitochondrial envelope.
SIGNOR-C411	Inner_mitochondrial_membrane	CHEBI:28494;CHEBI:16038;CHEBI:64482		The inner lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae GO:0005743.
SIGNOR-C412	TSH	P01222;P01215	CPX-6096	 TSH is a heterodimer composed of common alpha subunit and unique beta subunit encoded by genes located on different chromosomes.
SIGNOR-C413	NSL histone acetyltransferase	Q9P2N6;Q9H9L4;P61964;Q9BVI0;P51610;O15294;Q9H7Z6;Q96EZ8;Q7Z3B3	CPX-809	A histone acetyltransferase complex that catalyzes the acetylation of histone H4 on lysines 5, 8, and 16 but not on lysine 12.
SIGNOR-C414	PCC	P05165;P05166	CPX-6169	Propionyl-CoA carboxylase (PCC) is a biotin-dependent mitochondrial enzyme that catalyzes the conversion of propionyl-CoA to D-methylmalonyl-CoA.
SIGNOR-C415	NatA	Q9BXJ9;P41227	CPX-6271	NatA N-alpha-acetyltransferase complex
SIGNOR-C416	NatB 	Q14CX7;P61599	CPX-6270 	NatB complex catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln
SIGNOR-C417	NatC	Q5VZE5;Q9BRA0;Q147X3	CPX-6275	 N-terminal acetyltransferase C (NatC) complex catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly.
SIGNOR-C418	HIF-1 complex	Q16665;P27540	CPX-7381	Most, if not all, oxygen-breathing species express the highly conserved transcriptional complex HIF-1, which is a heterodimer composed of an alpha and a beta subunit, the latter being a constitutively-expressed aryl hydrocarbon receptor nuclear translocator (ARNT). (Wikipedia)
SIGNOR-C419	ORC	Q13415;Q13416;Q9Y5N6;O43913;Q9UBD5;O43929	CPX-1880	Nuclear origin of replication recognition complex
SIGNOR-C42	DNMT1/DNMT3A	Q9Y6K1;P26358
SIGNOR-C420	CyclinA2/CDK1	P06493;P20248	CPX-2004	Cyclin-dependent protein kinase complex.
SIGNOR-C421	TOM40 complex	Q9P0U1;Q8N4H5;Q96B49;Q15388;Q9NS69;O96008;O94826	CPX-6121	Translocase in the outer mitochondrial membrane that mediates the import of precursor protein and mediates inset of some resident outer membrane proteins.
SIGNOR-C422	SAM complex	Q13505;Q9Y512;O75431	CPX-6133	Mitochondrial sorting and assembly machinery
SIGNOR-C423	TIM23 complex	O14925;P38646;O43615;P60602;Q96DA6;Q99595;Q3ZCQ8;Q9BVV7;Q9Y3D7;Q8TAA5;Q9HAV7;Q9Y5T4	CPX-6129	Mitochondrial inner membrane pre-sequence translocase complex
SIGNOR-C424	TIM22 complex	Q9Y5J7;P62072;Q53H12;Q9BSF4;Q9Y584;Q6PF06	CPX-6124	Mitochondrial inner membrane twin-pore carrier translocase complex
SIGNOR-C425	Class I MHC	P61769;SIGNOR-PF87		The human class I Major Histocompatibility Complex (MHC I, also named the Human Leukocyte Antigen, HLA) consists of heavy (H) and light (L) chains, with the L chain being an invariant protein partner called beta-2 microglobulin (beta2m).
SIGNOR-C426	Class I MHC:Antigen	CHEBI:166824;SIGNOR-C425		The major histocompatibility complex (MHC) molecules, or human leukocyte antigens (HLA) in humans, bind these peptides to present them to T cells that recognise them with their surface T cell receptors (TCR).
SIGNOR-C427	Ubiquitinated-Viral_Protein	SIGNOR-PF89;SIGNOR-PF88
SIGNOR-C428	Class II MHC	SIGNOR-PF91;SIGNOR-PF90		Class II molecules are heterodimers consisting in two homogenous peptides, an α and β chain, both of which are encoded in the MHC.
SIGNOR-C429	Class II MHC:Antigen	CHEBI:166824;CHEBI:53000;SIGNOR-C428		MHC Class II molecules are a class of major histocompatibility complex (MHC) molecules that bind peptides that are derived from extracellular proteins.
SIGNOR-C43	DNMT1/DNMT3B	P26358;Q9UBC3
SIGNOR-C430	α-D-glucosyl-glycogenin	CHEBI:58885;SIGNOR-PF95
SIGNOR-C431	BMAL1/NPAS2	Q99743;O15516
SIGNOR-C432	CD3	P20963;P04234;P09693;P07766
SIGNOR-C433	BCR-Mk	P0DOX7;P11912;P40259;P0DOX6
SIGNOR-C434	BCR-Ml	P0DOX6;P11912;P40259;P0DOX8
SIGNOR-C435	BCR-Dk	P0DOX3;P11912;P40259;P0DOX7
SIGNOR-C436	BCR-Dl	P0DOX3;P11912;P40259;P0DOX8
SIGNOR-C437	Glycine cleavage system	P09622;P23378;P23434;P48728		The glycine cleavage system is a mitochondrial multienzyme system composed of four proteins termed P, H, T and L-protein, and catalyzes the reversible oxidation of glycine yielding carbon dioxide, ammonia, 5,10-methylenetetrahydrofolate (5,10-CH2-H4folate), and reduced pyridine nucleotide.
SIGNOR-C439	CCR4-NOT complex	O95628;Q9UFF9;Q9UIV1;Q9UKZ1;O75175;Q92600;Q96LI5;Q9C0C2;A5YKK6;Q9H9A5;Q9NZN8;Q9ULM6	CPX-707	 In the present study, we examine the composition of the human Ccr4-Not complex in an in-depth proteomic approach using stable cell lines expressing tagged CNOT proteins. We find at least four different variants of the human complex, consisting of seven stable core proteins and mutually exclusive associated mRNA deadenylase subunits. Interestingly, human CNOT4 is in a separate approximately 200 kDa complex. Furthermore, analyses of associated proteins indicate involvement of Ccr4-Not complexes in splicing, transport and localization of RNA molecules.
SIGNOR-C44	eIF4F_complex	Q04637;P06730;Q14240	CPX-5634
SIGNOR-C440	Cap-binding complex	P52298;Q09161	CPX-1427	The largely nuclear cap-binding complex (CBC) binds to the 5′ caps of RNA polymerase II (RNAPII)-synthesized transcripts and serves as a dynamic interaction platform for a myriad of RNA processing factors that regulate gene expression.
SIGNOR-C441	CSTF complex	P33240;Q05048;Q12996	CPX-2701	Cleavage stimulation factor (CstF) is a heterotrimer necessary for the first step, endonucleolytic cleavage, and it plays an important role in determining the efficiency of polyadenylation.
SIGNOR-C442	SF3b	O75533;Q13435;Q15393;Q15427;Q9BWJ5;Q9Y3B4;Q7RTV0	CPX-2227	Pre-mRNA splicing complex.
SIGNOR-C443	NF90-NF45	Q12905;Q12906
SIGNOR-C444	TREX complex	Q8NI27;Q86W42;Q13838;Q96J01;Q13769;Q86V81;Q6I9Y2;Q96FV9
SIGNOR-C445	Neuronal AP-3	Q13367;O14617;P53677;P59780	CPX-5053
SIGNOR-C446	MLL3 complex	Q8NEZ4;SIGNOR-C87
SIGNOR-C447	B-WICH complex	Q9UIG0;O00159;Q9NR30;Q03468;P35659;Q9BQG0;O60264;CHEBI:18111;O75533	CPX-1099
SIGNOR-C448	HNuRF	Q09028;P28370;Q16576;Q12830	CPX-688
SIGNOR-C449	WICH	O60264;Q9UIG0	CPX-757
SIGNOR-C450	GLI1/GLI2	P08151;P10070		GLI1 and GLI2 were shown to co-immunoprecipitate in PANC1 pancreatic cancer cells and RMS13 rhabdomyosarcoma cells.|Chromatin immunoprecipitation showed that GLI1 and GLI2 occupied the same regions at the BCL2, MYCN and CCND1 promoters. Furthermore, depletion of GLI1 inhibited GLI2 occupancy at these promoters, suggesting that GLI1/GLI2 interaction is required for the recruitment of GLI2 to these sites.
SIGNOR-C451	SOX17/POU5F1	Q9H6I2;Q01860		SOX17 partners with OCT4/POU5F1 and binds to a unique ‘compressed' Sox/Oct motif that earmarks endodermal genes
SIGNOR-C452	Ternary_GTP_eIF2_tRNA_complex	CHEBI:15996;P41091;CHEBI:16635;P05198;P20042	CPX-2716	In eukaryotes, translation initiation generally occurs by a cap-dependent scanning mechanism, wherein the small (40S) subunit of the ribosome recruits methionyl initiator tRNA (Met-tRNAi) in a ternary complex (TC) with GTP-bound eukaryotic initiation factor 2 (eIF2)
SIGNOR-C453	43S_pre_initiation_complex	SIGNOR-C286;SIGNOR-C401;SIGNOR-C452;P41567;P55010		43S pre-initiation complex (43S PIC), which consists of the 40S ribosomal subunit, translation initiation factors eIF1, eIF1A, eIF3, eIF5, and a ternary complex (TC) composed of eIF2, GTP and Met-tRNAiMet.
SIGNOR-C454	48S_initiation_complex	P23588;CHEBI:33699;SIGNOR-C453;SIGNOR-C44		The 48S complex scans mRNA from 5′ to 3′ until it identifies an AUG start codon in an appropriate sequence context (Kozak consensus)
SIGNOR-C455	80S_cytosolic_ribosome	SIGNOR-C286;SIGNOR-C287;CHEBI:33699		Complete structure of the eukaryotic ribosome, made of the large (60S) and small (40S) ribosomal subunits that assemble over the mRNA.
SIGNOR-C456	CAK complex	P51946;P50613;P51948	CPX-578	CdK activating kinase (CAK) complex, which harbors the kinase activity of CDK7 as well as the Cyclin H and MAT1 subunits
SIGNOR-C457	TFIIH	P18074;SIGNOR-C456;Q13889;Q92759;Q6P1K8;Q6ZYL4;P32780;P19447;Q13888	CPX-2395	Transcription factor IIH (TFIIH) is a heterodecameric protein complex critical for transcription initiation by RNA polymerase II and nucleotide excision DNA repair.
SIGNOR-C458	TFIIE	P29083;P29084	CPX-2394	The heterodimer TFIIE (composed of the TFIIEA and TFIIEB subunits) seems to play a pivotal role in transcription by directly influencing the transition from initiation to elongation
SIGNOR-C459	NuA4 complex	Q9NPF5;Q9NV56;Q9HAF1;Q9H2F5;Q52LR7;Q15014;Q9Y265;Q9Y230;Q15906;Q96L91;Q05BQ5;Q92993;Q9Y4A5;Q9NXR8;Q9H0E9;O96019;P60709;O95619;Q9UBU8	CPX-978
SIGNOR-C460	EEF1B complex	P26641;P29692;P24534		EEIF1A a guanine nucleotide exchange factor
SIGNOR-C461	HIRA complex 1	Q9Y6J0;P54198;Q9NPG3
SIGNOR-C462	HIRA complex 2	Q6ZU65;Q9Y6J0;P54198
SIGNOR-C463	ETF	CHEBI:456215;CHEBI:57692;P38117;P13804	CPX-2731
SIGNOR-C464	SL1 complex	Q15572;Q53T94;Q15573;P20226;Q9H5J8		SL1/TIF-IB complex or RNA polymerase I core complex, binds rDNA promoters and plays a role in Pol I recruitment
SIGNOR-C465	SAGA complex	O75529;Q7Z7C8;Q15573;Q86TJ2;Q96ES7;Q8NEM7;Q9NPA8;Q14CW9;Q96BN2;O75528;O94864;Q9Y6J9;Q16594;Q12962;Q9UPT9;Q92831;Q92830;Q6P1X5;Q9Y4A5;Q16514;O75486;O15265	CPX-900	A transcriptional co-activator complex that preferably acetylates histone H3 and possibly H4. Involved in chromatine remodelling and Pol II genes transcriptional activation.
SIGNOR-C466	Elongator complex	Q9H9T3;Q0PNE2;Q8TE02;O95163;Q96EB1;Q6IA86	CPX-1949
SIGNOR-C467	GBAF	O96019;Q4VC05;Q15532;Q9BQE9;Q92922;Q8WUZ0;P51531;Q96GM5;P60709;Q9H8M2;Q9NZM4	CPX-4084
SIGNOR-C468	RalGAP1	Q86X10;Q6GYQ0
SIGNOR-C469	RalGAP2	Q86X10;Q2PPJ7
SIGNOR-C47	ELF4/RUNX1	Q99607;Q01196
SIGNOR-C470	SWI/SNF ACTL6A-ARID1A-SMARCA2 variant	Q92925;Q969G3;Q6STE5;Q92922;Q96GM5;P51531;Q8TAQ2;P60709;O96019;O14497;Q12824	CPX-1164
SIGNOR-C471	PAF1C	Q6P1J9;Q8N7H5;Q6PD62;Q9GZS3;Q92541;Q8WVC0	CPX-2381
SIGNOR-C472	Multiaminoacyl-tRNA synthetase	Q15046;P14868;Q13155;O43324;Q12904;P47897;P54136;P07814;Q9P2J5;P41252;P56192	CPX-2469
SIGNOR-C473	Phenylalanyl-tRNA synthetase	Q9Y285;Q9NSD9	CPX-2208
SIGNOR-C474	MPO-ANCA	P0DOX5		Anti-MPO447–459 antibodies
SIGNOR-C475	Pr3-ANCA	P0DOX5		Anti-PR3 antibodies
SIGNOR-C476	SWI/SNF ACTL6B varian	P51532;Q92925;Q969G3;Q92922;Q8TAQ2;Q68CP9;O94805;Q9NPI1;P60709;Q96GM5;Q8WUB8;Q86U86;Q12824	CPX-1196
SIGNOR-C477	Neural progenitor-specific SWI/SNF	Q969G3;Q8TAQ2;Q92922;Q6STE5;P51531;Q96GM5;P60709;O96019;Q8WUB8;O14497;Q12824	CPX-1201
SIGNOR-C478	U4/U6.U5 snRNP complex	P62314;O75643;Q8WWY3;P62318;P14678;P62304;O43172;Q6P2Q9;Q9Y4Y9;O94906;O43290;O95777;P09012;P55769;P62306;P62308;P62310;P62312;P62316;P83876;Q15029;Q53GS9;Q8WVK2;Q96DI7;Q9BTD8;Q9BUQ8;Q9UK45;Q9Y333;Q9Y4Z0	CPX-2391	Under splicing conditions, the U4/U6 and U5 snRNPs form a 25S U4/U6.U5 tri-snRNP, in which the U4 and U6 snRNAs are base-paired, forming a three-way junction.
SIGNOR-C479	U2 snRNP complex	Q15459;Q9Y388;Q7L014;P09661;P08579;O43719;P62316;P62314;P62308;P62306;Q9BRD0;Q15428;Q12874;Q7RTV0;Q9Y3B4;Q9BWJ5;Q15427;Q15393;Q13435;P62304;P14678;P62318;Q8TAD8;O75533	CPX-2539	The U2 small nuclear ribonucleoprotein (snRNP) is an essential component of the spliceosome, the cellular machine responsible for removing introns from precursor mRNAs (pre-mRNAs) in all eukaryotes. U2 recognises the branch site sequence in introns.
SIGNOR-C48	ELL/ICE1	P55199;Q9Y2F5
SIGNOR-C480	U1 snRNP complex	P08621;P09234;P62316;P62314;P62308;P62306;P09012;P62304;P14678;P62318	CPX-2392	The U1 small nuclear ribonucleoprotein (snRNP) is an essential component of the spliceosome, the cellular machine responsible for removing introns from precursor mRNAs (pre-mRNAs) in all eukaryotes. The U1 snRNP recognizes the donor site sequence of the intron.
SIGNOR-C481	Muscle cell-specific SWI/SNF ARID1A variant	Q96GM5;Q8TAQ2;P51531;O96019;Q92784;O14497;Q12824;Q92925;Q969G3;Q6STE5;P60709;Q92922	CPX-1194
SIGNOR-C482	Muscle cell-specific SWI/SNF ARID1B variant	Q92784;Q8TAQ2;Q92922;Q6STE5;Q969G3;Q92925;Q12824;Q8NFD5;O96019;P60709;Q96GM5;P51531	CPX-1223
SIGNOR-C483	Muscle cell-specific SWI/SNF SMARCA4 variant	Q8TAQ2;Q92922;Q6STE5;Q969G3;Q92925;Q12824;P51532;O14497;O94805;Q92784;P60709;Q96GM5	CPX-1226
SIGNOR-C484	Embryonic stem cell-specific SWI/SNF	Q8WUB8;Q8WUZ0;Q92922;Q969G3;Q9BQE9;Q12824;P51532;O14497;Q92785;Q4VC05;O96019;P60709;Q96GM5	CPX-1195
SIGNOR-C485	Brain-specific SWI/SNF SMARCA2 variant	P60709;Q8TAQ2;Q969G3;Q92925;Q12824;O14497;O94805;P51531	CPX-1203
SIGNOR-C486	Brain-specific SWI/SNF SMARCA4 variant	O14497;P60709;O94805;P51532;Q12824;Q92925;Q969G3;Q8TAQ2	CPX-1219
SIGNOR-C487	COP9 signalosome variant 2	Q99627;Q9BT78;Q13098;Q92905;Q9H9Q2;Q7L5N1;P61201;Q9UNS2	CPX-1871
SIGNOR-C489	COP9 signalosome variant 1	Q92905;Q7L5N1;Q99627;Q9BT78;Q13098;Q9UNS2;Q9UBW8;P61201	CPX-1870
SIGNOR-C49	ELL/ICE2	Q659A1;P55199
SIGNOR-C491	Exocyst_EXOC6B variant	Q9Y2D4;O00471;O60645;Q96KP1;Q9NV70;Q9UPT5;Q96A65;Q8IYI6	CPX-4944
SIGNOR-C492	Exocyst_EXOC6 variant	O00471;O60645;Q9UPT5;Q9NV70;Q8IYI6;Q8TAG9;Q96A65;Q96KP1	CPX-4943
SIGNOR-C493	EEF1A:GTP:aa-tRNA	CHEBI:2651;CHEBI:15996;P68104
SIGNOR-C494	Translation release factor ERF1-ERF3	CHEBI:15996;P62495;P15170	CPX-2721
SIGNOR-C495	Ub:E1 (UBA1 substrate)	SIGNOR-PF89;P22314
SIGNOR-C496	Ub:E1 (UBA6 substrate)	A0AVT1;SIGNOR-PF89
SIGNOR-C497	Ub:E2	SIGNOR-PF105;SIGNOR-PF89
SIGNOR-C498	INO80 complex	O96019;Q6P4R8;Q6PI98;Q9H9F9;Q9H981;Q9C086;Q8NBZ0;Q53TQ3;Q9ULG1;P25490;P0C1Z6;Q9Y5K5;Q9Y230;Q9Y265;Q96EZ8	CPX-846
SIGNOR-C499	MCU_MICUB_variant	Q8NE86;Q9BPX6;Q9NWR8;Q8IYU8;Q9H4I9	CPX-5966
SIGNOR-C5	SCF-betaTRCP	P63208;Q13616;Q9Y297
SIGNOR-C50	ERCC4/ERCC1	Q92889;P07992	CPX-478
SIGNOR-C500	MCU_MICU1_variant	Q9H4I9;Q8NE86;Q9BPX6	CPX-5963
SIGNOR-C501	 MCU_MICU3_variant	Q86XE3;Q8NE86;Q9H4I9;Q9BPX6	CPX-5965
SIGNOR-C502	MCU_MICU2_variant	Q9BPX6;Q8IYU8;Q9H4I9;Q8NE86	CPX-5961
SIGNOR-C503	Scribble_complex_DLG2-LLGL2_variant	Q14160;Q15700;Q6P1M3	CPX-6184
SIGNOR-C504	Scribble_complex_DLG3-LLGL2_variant	Q6P1M3;Q92796;Q14160	CPX-6185
SIGNOR-C505	Scribble_complex_DLG4-LLGL2_variant	Q14160;Q6P1M3;P78352	CPX-6186
SIGNOR-C506	Scribble_complex_DLG5-LLGL2_variant	Q14160;Q6P1M3;Q8TDM6	CPX-6187
SIGNOR-C507	Scribble_complex_DLG3-LLGL1_variant	Q92796;Q14160;Q15334	CPX-6190
SIGNOR-C508	Scribble_complex_DLG5-LLGL1_variant	Q8TDM6;Q14160;Q15334	CPX-6188
SIGNOR-C509	Scribble_complex_DLG4-LLGL1_variant	Q14160;P78352;Q15334	CPX-6189
SIGNOR-C51	EXT1/EXT2	Q16394;Q93063
SIGNOR-C510	Scribble_complex_DLG2-LLGL1_variant	Q15334;Q15700;Q14160	CPX-6191
SIGNOR-C511	Scribble_complex_DLG1-LLGL1_variant	Q15334;Q14160;Q12959	CPX-6192
SIGNOR-C513	Prefoldin co-chaperone	P61758;Q99471;O60925;Q9UHV9;O15212;Q9NQP4	CPX-6149
SIGNOR-C514	URI1 prefoldin co-chaperone	O94763;Q9NUG6;O15212;Q9UHV9;Q9UBK9	CPX-6144
SIGNOR-C515	R2TP core co-chaperone	Q9NWS0;Q9Y265;Q9Y230;Q9H6T3	CPX-6143
SIGNOR-C516	PAQosome co-chaperone complex	P19388;L0R819;SIGNOR-C514;SIGNOR-C515;Q96MX6	CPX-6145
SIGNOR-C517	R2SP co-chaperone	Q9Y265;Q8WWB5;Q07617;Q9Y230	CPX-6150
SIGNOR-C518	Ub:HECT_E3 	SIGNOR-PF89;SIGNOR-PF104
SIGNOR-C519	Ub:RING_E3	SIGNOR-PF89;SIGNOR-PF106
SIGNOR-C52	FGFR1OP/CEP350	Q5VT06;O95684
SIGNOR-C520	Ub:RBR_E3	SIGNOR-PF89;SIGNOR-PF107
SIGNOR-C521	NELF	P18615;Q8IXH7;Q8WX92;Q9H3P2	CPX-6267
SIGNOR-C522	BAF250b E3 ligase	Q13617;P62877;Q15369;Q8NFD5
SIGNOR-C523	KPC	Q5XPI4;Q9BSL1
SIGNOR-C524	VCB-Cul2	Q13617;P62877;Q15370;P40337;Q15369
SIGNOR-C525	SCF-FBW2	Q9UKT8;P63208;Q13616
SIGNOR-C526	Cullin 3-RBX1-Skp1	P63208;P62877;Q13618
SIGNOR-C527	LUBAC	Q9BYM8;Q96EP0
SIGNOR-C528	Cullin 7-RBX1-Skp1	P63208;P62877;Q14999
SIGNOR-C529	Cullin 1-RBX1-Skp1	Q13616;P62877;P63208
SIGNOR-C53	CPSF complex	Q6UN15;Q10570;O95639;Q9UKF6;Q9P2I0	CPX-2698
SIGNOR-C530	EDVP	Q9Y4B6;Q16531;O95071
SIGNOR-C531	Elongin E3-Cul-5	Q15370;Q9UBF6;Q15369;Q93034
SIGNOR-C532	Erlin	O94905;O75477
SIGNOR-C533	SCF(TBL1)	Q8IUQ4;Q9UHX1;P63208;P25054;O60907
SIGNOR-C534	PRP19-CDC5L	P11142;Q8WYA6;O75934;Q9P013;O43660;Q99459;Q9UMS4	CPX-5824
SIGNOR-C535	OST-A complex	Q9NRP0;A0A024RAD5;P61165;P0C6T2;P04844;P61803;P46977;P04843	CPX-5621
SIGNOR-C536	OST-B complex	P61165;P39656;Q14165;Q9H0U3;P04843;P0C6T2;P04844;P61803;Q8TCJ2	CPX-5622
SIGNOR-C537	Skp1-Pam E3	O75592;P63208
SIGNOR-C538	MITRAC complex	Q9Y2R0;Q9GZY4;Q7Z7K0;Q96I36;Q9BVV7		MITRAC is a cytochrome c oxidase assembly intermediate complex that regulates mitochondrial translation in human mitochondria
SIGNOR-C539	TRiC	P48643;P50990;P78371;P49368;P50991;Q99832;P40227;P17987	CPX-6030
SIGNOR-C54	KAT6A/KAT6B	Q8WYB5;Q92794
SIGNOR-C540	CyclinY/CDK16	Q00536;Q8ND76	CPX-379	CDK16 (also known as PCTAIRE1 or PCTK1) is an atypical member of the cyclin-dependent kinase (CDK) family that forms an active complex with cyclin Y (CCNY).
SIGNOR-C541	CyclinY/CDK14	Q8ND76;O94921	CPX-364	Cyclin-dependent protein kinase complex which acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase.
SIGNOR-C542	CyclinD3/CDK11A	Q9UQ88;P30281		Kinase-cyclin complex formed by Cyclin D3 and CDK11A
SIGNOR-C543	CyclinD3/CDK11B	P21127;P30281		Kinase-cyclin complex formed by CDK11B (p58) and Cyclin D3
SIGNOR-C544	CyclinC/CDK19	P24863;Q9BWU1		Cyclin-CDK complex formed by CDK19 and CyclinC.
SIGNOR-C545	CyclinC/CDK3	Q00526;P24863	CPX-330	Cyclin-dependent protein kinase complex formed by CDK3 and Cyclin-C
SIGNOR-C546	CyclinE1/CDK3	Q00526;P24864		Cyclin-CDK complex formed by Cyclin E1 and CDK3, it promotes G1 to S phase transition
SIGNOR-C547	CyclinA2/CDK18	P20248;Q07002
SIGNOR-C548	Iws1:Spt6:CTD complex	Q7KZ85;Q96ST2;Q9BYW2
SIGNOR-C549	HOPS tethering complex	Q9H269;Q96AX1;Q9H270;P49754;Q9P253;Q96JC1	CPX-6212
SIGNOR-C55	KAT6A/PML	Q92794;P29590
SIGNOR-C550	CORVET tethering complex	Q9H270;Q9P253;Q96AX1;Q8N3P4;Q8WUH2;Q9H269	CPX-6213
SIGNOR-C551	STX17-VAMP8 SNARE complex	O95721;P56962;Q9BV40
SIGNOR-C552	STK35/PDIK1L	Q8N165;Q8TDR2
SIGNOR-C553	PAN2-PAN3 deadenylation complex	Q504Q3;Q58A45
SIGNOR-C554	CPC	Q9NQS7;Q53HL2;Q96GD4;O15392	CPX-116
SIGNOR-C555	CBM	Q9BXL7;O95999;Q9UDY8
SIGNOR-C556	YAP1/TAZ	Q9GZV5;P46937		Transcription coactivators YAP/TAZ
SIGNOR-C56	KCNJ5/KCNJ3	P48544;P48549	CPX-3278
SIGNOR-C58	MLH1/PMS1	P54277;P40692
SIGNOR-C59	MLH1/PMS2	P40692;P54278
SIGNOR-C6	CBP/p300	Q09472;Q92793
SIGNOR-C60	MSH2/MSH6	P52701;P43246	CPX-80
SIGNOR-C61	MSN/PDZD8	Q8NEN9;P26038
SIGNOR-C62	NONO/SFPQ	P23246;Q15233
SIGNOR-C64	POT1/ACD	Q96AP0;Q9NUX5
SIGNOR-C65	RAD51B/RAD51C	O43502;O15315
SIGNOR-C67	RBM15/NXF1	Q96T37;Q9UBU9
SIGNOR-C68	REL/RELA	Q04864;Q04206	CPX-5834
SIGNOR-C7	P300/PCAF	Q92793;Q92831;Q09472
SIGNOR-C71	SEPT6/SEPT2	Q15019;Q14141
SIGNOR-C72	SEPT6/SEPT7	Q14141;Q16181
SIGNOR-C73	SOX2/POU5F1	Q01860;P48431
SIGNOR-C74	SP1/STAT3	P40763;P08047
SIGNOR-C75	SS18/MLLT10	Q15532;P55197
SIGNOR-C76	SUZ12/EED	Q15022;O75530
SIGNOR-C77	SUZ12/EZH2	Q15910;Q15022
SIGNOR-C78	U2AF1/U2AF2	Q01081;P26368	CPX-1921
SIGNOR-C8	SMAD2/SMAD4	Q13485;Q15796	CPX-3208
SIGNOR-C80	ZBTB16/ZBTB32	Q9Y2Y4;Q05516
SIGNOR-C81	ZRSR2/U2AF2	Q15696;P26368
SIGNOR-C83	CyclinA2/CDK2	P20248;P24941	CPX-2006
SIGNOR-C84	NR3C1/STAT5A	P42229;P04150
SIGNOR-C85	SMAD1/4	Q13485;Q15797	CPX-54
SIGNOR-C86	SMAD3/JUN	P84022;P05412
SIGNOR-C87	MLL/SET subcomplex	Q15291;SIGNOR-C352;Q9C005;Q9UPS6
SIGNOR-C88	MLL2 complex	SIGNOR-C87;O14686
SIGNOR-C89	MLL1 complex	SIGNOR-C87;Q03164
SIGNOR-C9	SMAD3/SMAD4	P84022;Q13485	CPX-3252	SMAD3/SMAD4
SIGNOR-C90	PAX7/MLL1 complex	P23759;SIGNOR-C89
SIGNOR-C91	PAX7/MLL2 complex	SIGNOR-C88;P23759
SIGNOR-C92	SWI/SNF complex	O14497;Q969G3;Q8NFD5;Q12824;O96019;Q68CP9;Q8TAQ2;Q96GM5;P51532;Q92922
SIGNOR-C93	MYOD1/SWI/SNF complex	P15172;SIGNOR-C92;P40424
SIGNOR-C94	Myog/SWI/SNF complex	SIGNOR-C92;Q14814;P15173
SIGNOR-C95	CDON/BOC/PTCH1	Q4KMG0;Q9BWV1;Q13635		CDON/BOC/PTCH1
SIGNOR-C97	RBPJ/NOTCH	Q06330;P46531;SIGNOR-PF30		RBPJ/NOTCH
SIGNOR-C98	gamma-secretase	Q96BI3;Q9NZ42;Q92542;P49768	CPX-2176	gamma-secretase