AMPK	complex	SIGNOR-C15	SIGNOR	TP53	protein	P04637	UNIPROT	up-regulates	phosphorylation	Ser15	PSVEPPLsQETFSDL	9606									15866171	t		lperfetto	Ampk activation induces phosphorylation of p53 on serine 15, and this phosphorylation is required to initiate ampk-dependent cell-cycle arrest	SIGNOR-216475		factor	NA	0.417	Shortest
AMPK	complex	SIGNOR-C15	SIGNOR	CTBP1	protein	Q13363	UNIPROT	down-regulates	phosphorylation	Ser158	REGTRVQsVEQIREV	9606									23291169	t		lperfetto	We found that an activated amp-activated protein kinase (ampk) phosphorylates ctbp1 on ser-158 upon metabolic stresses. Moreover, ampk-mediated phosphorylation of ctbp1 (s158) attenuates the repressive function of ctbp1	SIGNOR-216604			NA	0.2	Shortest
BRCA1	protein	P38398	UNIPROT	DNA_repair	phenotype	SIGNOR-PH57	SIGNOR	up-regulates				NA									15549093	f		lperfetto	The BRCA1 protein also contributes to cell-cycle arrest and DNA repair by homologous recombination	SIGNOR-251500		phenotypesList	NA	0.7	Shortest
TP53	protein	P04637	UNIPROT	OGG1	protein	O15527	UNIPROT	up-regulates quantity by expression	transcriptional regulation			9606									16293709	t		miannu	Using gel-shift assays, we showed that p53 binds to its putative cis-elements within the hOGG1 promoter. In addition we demonstrated that supplementing p53 in HCT116p53-/- cells enhanced the transcription of hOGG1.	SIGNOR-255440	factor		NA	0.448	Shortest
MLH1	protein	P40692	UNIPROT	DNA_repair	phenotype	SIGNOR-PH57	SIGNOR	up-regulates activity				10090									9500552	f			Germline mutations in the human MSH2, MLH1, PMS2 and PMS1 DNA mismatch repair (MMR) gene homologues appear to be responsible for most cases of hereditary non-polyposis colorectal cancer	SIGNOR-257595		phenotypesList	NA	0.7	Shortest
PMS2	protein	P54278	UNIPROT	DNA_repair	phenotype	SIGNOR-PH57	SIGNOR	up-regulates activity				10090									9500552	f			Germline mutations in the human MSH2, MLH1, PMS2 and PMS1 DNA mismatch repair (MMR) gene homologues appear to be responsible for most cases of hereditary non-polyposis colorectal cancer	SIGNOR-257596		phenotypesList	NA	0.7	Shortest
TP53	protein	P04637	UNIPROT	PMS2	protein	P54278	UNIPROT	up-regulates quantity	transcriptional regulation			9606									15781865	t			.... numerous potentially novel targets, including the DNA mismatch repair genes MLH1 and PMS2. Both of these genes were determined to be responsive to DNA damage and p53 activation in normal human fibroblasts, and have p53-response elements within their first intron.	SIGNOR-257604	factor		NA	0.566	Shortest
TP53	protein	P04637	UNIPROT	MLH1	protein	P40692	UNIPROT	up-regulates quantity	transcriptional regulation			9606									15781865	t			.... numerous potentially novel targets, including the DNA mismatch repair genes MLH1 and PMS2. Both of these genes were determined to be responsive to DNA damage and p53 activation in normal human fibroblasts, and have p53-response elements within their first intron.	SIGNOR-257605	factor		NA	0.596	Shortest
CTBP1	protein	Q13363	UNIPROT	BRCA1	protein	P38398	UNIPROT	down-regulates quantity by repression	transcriptional regulation			9606									21681822	t		irozzo	Carboxyl-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor with oncogenic potential. We found CtBP1 was recruited to the promoter regions of Brca1 and E-cadherin genes in breast cancer cells.	SIGNOR-259196			NA	0.582	Shortest
OGG1	protein	O15527	UNIPROT	DNA_repair	phenotype	SIGNOR-PH57	SIGNOR	up-regulates				10090									26221032	f		miannu	Cut repeats from the CUX1 protein were recently shown to stimulate 8-oxoguanine DNA glycosylase 1 (OGG1), an enzyme that removes oxidized purines from DNA and introduces a single strand break through its apurinic/apyrimidinic lyase activity to initiate base excision repair.	SIGNOR-263959		phenotypesList	NA	0.7	Shortest