| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1023 | phosphorylation down-regulates ⊣ | ERBB2 | 1706616 | SIGNOR-251129 |
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1112 | phosphorylation down-regulates ⊣ | ERBB2 | 1706616 | SIGNOR-21211 |
| ERBB2 | phosphorylation up-regulates → | SHCBP1 PSer273 | phosphorylation down-regulates ⊣ | SHCBP1 | 35013128 | SIGNOR-280009 |
| AXL | phosphorylation up-regulates → | ERBB2 P | phosphorylation down-regulates ⊣ | ERBB2 | 20818175 | SIGNOR-280193 |
| ERBB2 | phosphorylation up-regulates → | DOCK7 PTyr1257 | phosphorylation down-regulates ⊣ | DOCK7 | 18426980 | SIGNOR-178348 |
| ERBB2 | phosphorylation up-regulates → | BBC3 PTyr58 | phosphorylation down-regulates ⊣ | BBC3 | 24236056 | SIGNOR-276473 |
| PTPN18 | dephosphorylation up-regulates → | ERBB2 P | dephosphorylation down-regulates ⊣ | ERBB2 | 25081058 | SIGNOR-277031 |
| AREG | phosphorylation up-regulates → | ERBB2 P | phosphorylation down-regulates ⊣ | ERBB2 | 7679104 | SIGNOR-31199 |
| PRKACA | phosphorylation up-regulates → | ERBB2 PThr686 | phosphorylation down-regulates ⊣ | ERBB2 | 18799465 | SIGNOR-181191 |
| DUSP3 | dephosphorylation up-regulates → | ERBB2 PTyr1221 | dephosphorylation down-regulates ⊣ | ERBB2 | 21262974 | SIGNOR-248534 |
| CDK5 | phosphorylation up-regulates → | ERBB2 P | phosphorylation down-regulates ⊣ | ERBB2 | 26509276 | SIGNOR-279155 |
| AKT1 | phosphorylation up-regulates → | VCP PSer746 | phosphorylation down-regulates ⊣ | VCP | 16551632 | SIGNOR-252492 |
| ERBB2 | phosphorylation up-regulates → | ABL1 P | phosphorylation down-regulates ⊣ | ABL1 | 19275932 | SIGNOR-279407 |
| PTPN18 | dephosphorylation up-regulates → | ERBB2 PTyr1196 | dephosphorylation down-regulates ⊣ | ERBB2 | 25081058 | SIGNOR-262596 |
| ERBB2 | phosphorylation up-regulates → | PTK2 PTyr397 | phosphorylation down-regulates ⊣ | PTK2 | 27638858 | SIGNOR-278475 |
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1221 | phosphorylation down-regulates ⊣ | ERBB2 | 1706616 | SIGNOR-21199 |
| ERBB2 | phosphorylation up-regulates → | ERBB3 P | phosphorylation down-regulates ⊣ | ERBB3 | 23912457 | SIGNOR-278200 |
| ERBB2 | phosphorylation up-regulates → | MBD4 P | phosphorylation down-regulates ⊣ | MBD4 | 22964581 | SIGNOR-279408 |
| PTPRO | dephosphorylation up-regulates → | LYN P | dephosphorylation down-regulates ⊣ | LYN | 20564182 | SIGNOR-277144 |
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1222 | phosphorylation down-regulates ⊣ | ERBB2 | 15156151 | SIGNOR-124860 |
| PTPN11 | dephosphorylation up-regulates → | ERBB2 PTyr1023 | dephosphorylation down-regulates ⊣ | ERBB2 | 32024694 | SIGNOR-262957 |
| ERBB2 | phosphorylation up-regulates → | ESR1 P | phosphorylation down-regulates ⊣ | ESR1 | 15173068 | SIGNOR-124962 |
| ERBB2 | phosphorylation up-regulates → | CDK1 PTyr15 | phosphorylation down-regulates ⊣ | CDK1 | 12049736 | SIGNOR-88671 |
| PTPRO | dephosphorylation up-regulates → | STAT3 PSer727 | dephosphorylation down-regulates ⊣ | STAT3 | 24708807 | SIGNOR-277061 |
| AKT1 | phosphorylation up-regulates → | VCP PSer352 | phosphorylation down-regulates ⊣ | VCP | 16551632 | SIGNOR-252491 |
| PTPN18 | dephosphorylation up-regulates → | ERBB2 PTyr1112 | dephosphorylation down-regulates ⊣ | ERBB2 | 25081058 | SIGNOR-262595 |
| PTPN12 | dephosphorylation up-regulates → | ERBB2 PTyr1196 | dephosphorylation down-regulates ⊣ | ERBB2 | 29330094 | SIGNOR-277038 |
| PTPN3 | dephosphorylation up-regulates → | VCP PTyr805 | dephosphorylation down-regulates ⊣ | VCP | 10364224 | SIGNOR-248461 |
| AKT | phosphorylation up-regulates → | VCP PSer352 | phosphorylation down-regulates ⊣ | VCP | 16551632 | SIGNOR-145284 |
| ERBB2 | phosphorylation up-regulates → | EGFR PTyr1197 | phosphorylation down-regulates ⊣ | EGFR | 23027125 | SIGNOR-278474 |
| PTPRG | dephosphorylation up-regulates → | ERBB2 PTyr1248 | dephosphorylation down-regulates ⊣ | ERBB2 | 25624455 | SIGNOR-254701 |
| AKT | phosphorylation up-regulates → | VCP PSer746 | phosphorylation down-regulates ⊣ | VCP | 16551632 | SIGNOR-145288 |
| AKT1 | phosphorylation up-regulates → | VCP PSer748 | phosphorylation down-regulates ⊣ | VCP | 16551632 | SIGNOR-252493 |
| PTPRO | dephosphorylation up-regulates → | VCP P | dephosphorylation down-regulates ⊣ | VCP | 23533167 | SIGNOR-277063 |
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1248 | phosphorylation down-regulates ⊣ | ERBB2 | 1706616 | SIGNOR-251128 |
| PTPRO | dephosphorylation up-regulates → | STAT3 PTyr705 | dephosphorylation down-regulates ⊣ | STAT3 | 24708807 | SIGNOR-277062 |
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1222 | phosphorylation down-regulates ⊣ | ERBB2 | 1706616 | SIGNOR-251130 |
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1196 | phosphorylation down-regulates ⊣ | ERBB2 | 15156151 | SIGNOR-124856 |
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1139 | phosphorylation down-regulates ⊣ | ERBB2 | 1706616 | SIGNOR-251127 |
| PTPRO | dephosphorylation up-regulates → | ERBB2 PTyr1248 | dephosphorylation down-regulates ⊣ | ERBB2 | 27345410 | SIGNOR-276979 |
| ERBB2 | phosphorylation up-regulates → | ERBB2 PTyr1248 | phosphorylation down-regulates ⊣ | ERBB2 | 1706616 | SIGNOR-21203 |
| ERBB2 | phosphorylation up-regulates → | CTNNB1 PTyr654 | phosphorylation down-regulates ⊣ | CTNNB1 | 23576562 | SIGNOR-279041 |
| ERBB2 | phosphorylation up-regulates → | ErbB receptor family P | phosphorylation down-regulates ⊣ | ErbB receptor family | 1706616 | SIGNOR-269875 |
| ERBB2 | phosphorylation up-regulates → | BBC3 PTyr172 | phosphorylation down-regulates ⊣ | BBC3 | 24236056 | SIGNOR-276474 |
| PTPN18 | dephosphorylation up-regulates → | ERBB2 PTyr1248 | dephosphorylation down-regulates ⊣ | ERBB2 | 25081058 | SIGNOR-262597 |
| DUSP3 | dephosphorylation up-regulates → | ERBB2 PTyr877 | dephosphorylation down-regulates ⊣ | ERBB2 | 21262974 | SIGNOR-248533 |
| PTPN3 | dephosphorylation up-regulates → | VCP PTyr796 | dephosphorylation down-regulates ⊣ | VCP | 10364224 | SIGNOR-248460 |
| EGFR | phosphorylation up-regulates → | ERBB2 PTyr1248 | phosphorylation down-regulates ⊣ | ERBB2 | 12354693 | SIGNOR-251094 |
| PTPN9 | dephosphorylation up-regulates → | ERBB2 P | dephosphorylation down-regulates ⊣ | ERBB2 | 20335174 | SIGNOR-277170 |
| JAK2 | phosphorylation up-regulates → | ERBB2 P | phosphorylation down-regulates ⊣ | ERBB2 | 10938266 | SIGNOR-279197 |
| AKT | phosphorylation up-regulates → | VCP PSer748 | phosphorylation down-regulates ⊣ | VCP | 16551632 | SIGNOR-145292 |
| PTPN13 | dephosphorylation up-regulates → | ERBB2 P | dephosphorylation down-regulates ⊣ | ERBB2 | 19734941 | SIGNOR-277087 |
| ERBB2 | phosphorylation up-regulates → | FASN P | phosphorylation down-regulates ⊣ | FASN | 27692180 | SIGNOR-278399 |
| SRC | phosphorylation up-regulates → | ERBB2 P | phosphorylation down-regulates ⊣ | ERBB2 | 26114632 | SIGNOR-279432 |
| ERBB2 | phosphorylation up-regulates → | BBC3 P | phosphorylation down-regulates ⊣ | BBC3 | 24236056 | SIGNOR-278224 |
| PTPRO | dephosphorylation up-regulates → | SRC PTyr419 | dephosphorylation down-regulates ⊣ | SRC | 25301722 | SIGNOR-277004 |
| ERBB2 | phosphorylation up-regulates → | BBC3 PTyr152 | phosphorylation down-regulates ⊣ | BBC3 | 24236056 | SIGNOR-276472 |
