| Name | SGK1 |
| ID | O00141 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 98-355 PROSITE-ProRule
AGC-kinase C-terminal 356-431 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK1 | FOXO | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates activity | 11154281 | SIGNOR-252987 |
| SGK1 | NR3C1 | Ser203 | DLEFSSGsPGKETNE | phosphorylation up-regulates activity | 23650397 | SIGNOR-251669 |
| SGK1 | NCSTN | Ser437 | FLRARNIsGVVLADH | phosphorylation down-regulates quantity | 22590650 | SIGNOR-280122 |
| SGK1 | SLC9A1 | Ser703 | MSRARIGsDPLAYEP | phosphorylation up-regulates activity | 25270604 | SIGNOR-280123 |
| SGK1 | SP1 | – | phosphorylation up-regulates activity | 28358001 | SIGNOR-279246 | |
| SGK1 | MAPK1 | Ser29 | GPRYTNLsYIGEGAY | phosphorylation up-regulates activity | 19447520 | SIGNOR-276223 |
| SGK1 | FOXO3 | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates activity | 11154281 | SIGNOR-236607 |
| SGK1 | MKNK1 | Ser353 | S-->K | phosphorylation down-regulates activity | 28545025 | SIGNOR-277357 |
| SGK1 | NDRG2 | Ser332 | LSRSRTAsLTSAASV | phosphorylation up-regulates | 15461589 | SIGNOR-129672 |
| SGK1 | NEDD4L | Ser342 | SSRLRSCsVTDAVAE | phosphorylation up-regulates | 11742982 | SIGNOR-113052 |
| SGK1 | MAP3K3 | Ser337 | DPRGRLRsADSENAL | phosphorylation down-regulates activity | 12392720 | SIGNOR-250005 |
| SGK1 | MAPT | Ser214 | GGKERPGsKEEVDED | phosphorylation down-regulates | 16982696 | SIGNOR-161288 |
| SGK1 | TRPV4 | Ser824 | LRRDRWSsVVPRVVE | phosphorylation up-regulates activity | 25972993 | SIGNOR-279386 |
| SGK1 | TSC2 | Ser1130 | GARDRVRsMSGGHGL | phosphorylation down-regulates activity | 27451907 | SIGNOR-277266 |
| SGK1 | MLLT3 | – | phosphorylation down-regulates activity | 25817867 | SIGNOR-279111 | |
| SGK1 | NDRG1 | Thr366 | GTRSRSHtSEGAHLD | phosphorylation up-regulates | 18787837 | SIGNOR-180829 |
| SGK1 | NEDD4L | – | phosphorylation down-regulates activity | 15586017 | SIGNOR-251949 | |
| SGK1 | NR3C1 | Ser211 | PGKETNEsPWRSDLL | phosphorylation up-regulates activity | 23650397 | SIGNOR-251670 |
| SGK1 | MAP3K3 | Ser166 | EPRSRHLsVSSQNPG | phosphorylation down-regulates activity | 12392720 | SIGNOR-250004 |
| SGK1 | FBXW7 | Ser227 | QQRRRITsVQPPTGL | phosphorylation up-regulates | 21147854 | SIGNOR-170404 |
| SGK1 | FOXO | Ser315 | DFRSRTNsNASTVSG | phosphorylation down-regulates activity | 11154281 | SIGNOR-252989 |
| SGK1 | NDRG2 | Thr348 | GNRSRSRtLSQSSES | phosphorylation up-regulates | 15461589 | SIGNOR-129680 |
| SGK1 | FOXO1 | Thr24 | LPRPRSCtWPLPRPE | phosphorylation down-regulates activity | 19965929 | SIGNOR-255925 |
| SGK1 | CDKN1B | Thr198 | PGLRRRQt | phosphorylation down-regulates activity | 18570873 | SIGNOR-179121 |
| SGK1 | CDKN1B | Thr157 | GIRKRPAtDDSSTQN | phosphorylation down-regulates | 18570873 | SIGNOR-179117 |
| SGK1 | STAT1 | – | phosphorylation up-regulates activity | 30382187 | SIGNOR-279281 | |
| SGK1 | SLC9A3 | Ser663 | TMRKRLEsFKSTKLG | phosphorylation up-regulates activity | 21054167 | SIGNOR-279112 |
| SGK1 | NCSTN | Ser437 | FLRARNIsGVVLADH | phosphorylation down-regulates quantity by destabilization | 22590650 | SIGNOR-276415 |
| SGK1 | APBB1 | Ser610 | ECRVRFLsFLAVGRD | phosphorylation down-regulates activity | 26188042 | SIGNOR-278220 |
| SGK1 | KMT2D | Ser1331 | RGRARLKsTASSIET | phosphorylation down-regulates activity | 30943409 | SIGNOR-277447 |
| SGK1 | CHUK | Thr23 | EMRERLGtGGFGNVC | phosphorylation up-regulates activity | 19088076 | SIGNOR-278987 |
| SGK1 | VDAC1 | Ser104 | LTFDSSFsPNTGKKN | phosphorylation down-regulates quantity | 30929899 | SIGNOR-278988 |
| SGK1 | WNK4 | Ser1217 | PGIMRRNsLSGSSTG | phosphorylation down-regulates activity | 27517916 | SIGNOR-278453 |
| SGK1 | MAP3K3 | Ser166 | EPRSRHLsVSSQNPG | phosphorylation down-regulates activity | 12761204 | SIGNOR-101211 |
| SGK1 | SLC1A3 | Thr482 | LDRLRTTtNVLGDSL | phosphorylation up-regulates activity | 12911626 | SIGNOR-263075 |
| SGK1 | BRAF | – | phosphorylation down-regulates activity | 11410590 | SIGNOR-279110 | |
| SGK1 | HTT | Ser419 | GGRSRSGsIVELIAG | phosphorylation down-regulates | 14725621 | SIGNOR-121349 |
| SGK1 | NDRG1 | Ser330 | LMRSRTAsGSSVTSL | phosphorylation down-regulates | 20416281 | SIGNOR-164898 |
| SGK1 | NDRG1 | Thr346 | GTRSRSHtSEGTRSR | phosphorylation up-regulates | 18787837 | SIGNOR-180821 |
| SGK1 | SLC2A4 | Ser274 | LERERPLsLLQLLGS | phosphorylation up-regulates activity | 17382906 | SIGNOR-236653 |
| SGK1 | NEDD4L | Ser448 | IRRPRSLsSPTVTLS | phosphorylation down-regulates | 15677482 | SIGNOR-133438 |
| SGK1 | WNK4 | Ser1190 | SSRQRRLsKGSFPTS | phosphorylation down-regulates activity | 27517916 | SIGNOR-278454 |
| SGK1 | FOXO3 | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 11154281 | SIGNOR-249134 |
| SGK1 | NDRG2 | Thr330 | TRLSRSRtASLTSAA | phosphorylation up-regulates | 15461589 | SIGNOR-129676 |
| SGK1 | MKNK1 | Ser352 | SEAKDLIsKLLVRDA | phosphorylation down-regulates activity | 28545025 | SIGNOR-277357 |
| SGK1 | FOXO3 | Ser253 | APRRRAVsMDNSNKY | phosphorylation down-regulates activity | 11154281 | SIGNOR-249133 |
| SGK1 | NEDD4L | Thr383 | PSVAYVHtTPGLPSG | phosphorylation down-regulates activity | 12911626 | SIGNOR-263076 |
| SGK1 | FOXO | Thr32 | QSRPRSCtWPLQRPE | phosphorylation down-regulates activity | 11154281 | SIGNOR-252988 |
| SGK1 | NDRG1 | Thr356 | GTRSRSHtSEGTRSR | phosphorylation up-regulates | 18787837 | SIGNOR-180825 |
| SGK1 | MAP3K3 | Ser337 | DPRGRLRsADSENAL | phosphorylation down-regulates activity | 12761205 | SIGNOR-101216 |
| SGK1 | TSC2 | Ser1132 | RDRVRSMsGGHGLRV | phosphorylation down-regulates activity | 27451907 | SIGNOR-277265 |
| SGK1 | WNK4 | Ser1201 | FPTSRRNsLQRSEPP | phosphorylation up-regulates activity | 23054253 | SIGNOR-276421 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK1 | phosphorylation up-regulates → | FOXO PSer253 | phosphorylation down-regulates ⊣ | FOXO | 11154281 | SIGNOR-252987 |
| SGK1 | phosphorylation up-regulates → | NR3C1 PSer203 | phosphorylation up-regulates → | NR3C1 | 23650397 | SIGNOR-251669 |
| SGK1 | phosphorylation up-regulates → | NCSTN PSer437 | phosphorylation down-regulates ⊣ | NCSTN | 22590650 | SIGNOR-280122 |
| SGK1 | phosphorylation up-regulates → | SLC9A1 PSer703 | phosphorylation up-regulates → | SLC9A1 | 25270604 | SIGNOR-280123 |
| SGK1 | phosphorylation up-regulates → | MAPK1 PSer29 | phosphorylation up-regulates → | MAPK1 | 19447520 | SIGNOR-276223 |
| SGK1 | phosphorylation up-regulates → | FOXO3 PSer315 | phosphorylation down-regulates ⊣ | FOXO3 | 11154281 | SIGNOR-236607 |
| SGK1 | phosphorylation up-regulates → | MKNK1 PSer353 | phosphorylation down-regulates ⊣ | MKNK1 | 28545025 | SIGNOR-277357 |
| SGK1 | phosphorylation up-regulates → | NDRG2 PSer332 | phosphorylation up-regulates → | NDRG2 | 15461589 | SIGNOR-129672 |
| SGK1 | phosphorylation up-regulates → | NEDD4L PSer342 | phosphorylation up-regulates → | NEDD4L | 11742982 | SIGNOR-113052 |
| SGK1 | phosphorylation up-regulates → | MAP3K3 PSer337 | phosphorylation down-regulates ⊣ | MAP3K3 | 12392720 | SIGNOR-250005 |
| SGK1 | phosphorylation up-regulates → | MAPT PSer214 | phosphorylation down-regulates ⊣ | MAPT | 16982696 | SIGNOR-161288 |
| SGK1 | phosphorylation up-regulates → | TRPV4 PSer824 | phosphorylation up-regulates → | TRPV4 | 25972993 | SIGNOR-279386 |
| SGK1 | phosphorylation up-regulates → | TSC2 PSer1130 | phosphorylation down-regulates ⊣ | TSC2 | 27451907 | SIGNOR-277266 |
| SGK1 | phosphorylation up-regulates → | NDRG1 PThr366 | phosphorylation up-regulates → | NDRG1 | 18787837 | SIGNOR-180829 |
| SGK1 | phosphorylation up-regulates → | NR3C1 PSer211 | phosphorylation up-regulates → | NR3C1 | 23650397 | SIGNOR-251670 |
| SGK1 | phosphorylation up-regulates → | MAP3K3 PSer166 | phosphorylation down-regulates ⊣ | MAP3K3 | 12392720 | SIGNOR-250004 |
| SGK1 | phosphorylation up-regulates → | FBXW7 PSer227 | phosphorylation up-regulates → | FBXW7 | 21147854 | SIGNOR-170404 |
| SGK1 | phosphorylation up-regulates → | FOXO PSer315 | phosphorylation down-regulates ⊣ | FOXO | 11154281 | SIGNOR-252989 |
| SGK1 | phosphorylation up-regulates → | NDRG2 PThr348 | phosphorylation up-regulates → | NDRG2 | 15461589 | SIGNOR-129680 |
| SGK1 | phosphorylation up-regulates → | FOXO1 PThr24 | phosphorylation down-regulates ⊣ | FOXO1 | 19965929 | SIGNOR-255925 |
| SGK1 | phosphorylation up-regulates → | CDKN1B PThr198 | phosphorylation down-regulates ⊣ | CDKN1B | 18570873 | SIGNOR-179121 |
| SGK1 | phosphorylation up-regulates → | CDKN1B PThr157 | phosphorylation down-regulates ⊣ | CDKN1B | 18570873 | SIGNOR-179117 |
| SGK1 | phosphorylation up-regulates → | SLC9A3 PSer663 | phosphorylation up-regulates → | SLC9A3 | 21054167 | SIGNOR-279112 |
| SGK1 | phosphorylation up-regulates → | NCSTN PSer437 | phosphorylation down-regulates ⊣ | NCSTN | 22590650 | SIGNOR-276415 |
| SGK1 | phosphorylation up-regulates → | APBB1 PSer610 | phosphorylation down-regulates ⊣ | APBB1 | 26188042 | SIGNOR-278220 |
| SGK1 | phosphorylation up-regulates → | KMT2D PSer1331 | phosphorylation down-regulates ⊣ | KMT2D | 30943409 | SIGNOR-277447 |
| SGK1 | phosphorylation up-regulates → | CHUK PThr23 | phosphorylation up-regulates → | CHUK | 19088076 | SIGNOR-278987 |
| SGK1 | phosphorylation up-regulates → | VDAC1 PSer104 | phosphorylation down-regulates ⊣ | VDAC1 | 30929899 | SIGNOR-278988 |
| SGK1 | phosphorylation up-regulates → | WNK4 PSer1217 | phosphorylation down-regulates ⊣ | WNK4 | 27517916 | SIGNOR-278453 |
| SGK1 | phosphorylation up-regulates → | MAP3K3 PSer166 | phosphorylation down-regulates ⊣ | MAP3K3 | 12761204 | SIGNOR-101211 |
| SGK1 | phosphorylation up-regulates → | SLC1A3 PThr482 | phosphorylation up-regulates → | SLC1A3 | 12911626 | SIGNOR-263075 |
| SGK1 | phosphorylation up-regulates → | HTT PSer419 | phosphorylation down-regulates ⊣ | HTT | 14725621 | SIGNOR-121349 |
| SGK1 | phosphorylation up-regulates → | NDRG1 PSer330 | phosphorylation down-regulates ⊣ | NDRG1 | 20416281 | SIGNOR-164898 |
| SGK1 | phosphorylation up-regulates → | NDRG1 PThr346 | phosphorylation up-regulates → | NDRG1 | 18787837 | SIGNOR-180821 |
| SGK1 | phosphorylation up-regulates → | SLC2A4 PSer274 | phosphorylation up-regulates → | SLC2A4 | 17382906 | SIGNOR-236653 |
| SGK1 | phosphorylation up-regulates → | NEDD4L PSer448 | phosphorylation down-regulates ⊣ | NEDD4L | 15677482 | SIGNOR-133438 |
| SGK1 | phosphorylation up-regulates → | WNK4 PSer1190 | phosphorylation down-regulates ⊣ | WNK4 | 27517916 | SIGNOR-278454 |
| SGK1 | phosphorylation up-regulates → | FOXO3 PThr32 | phosphorylation down-regulates ⊣ | FOXO3 | 11154281 | SIGNOR-249134 |
| SGK1 | phosphorylation up-regulates → | NDRG2 PThr330 | phosphorylation up-regulates → | NDRG2 | 15461589 | SIGNOR-129676 |
| SGK1 | phosphorylation up-regulates → | MKNK1 PSer352 | phosphorylation down-regulates ⊣ | MKNK1 | 28545025 | SIGNOR-277357 |
| SGK1 | phosphorylation up-regulates → | FOXO3 PSer253 | phosphorylation down-regulates ⊣ | FOXO3 | 11154281 | SIGNOR-249133 |
| SGK1 | phosphorylation up-regulates → | NEDD4L PThr383 | phosphorylation down-regulates ⊣ | NEDD4L | 12911626 | SIGNOR-263076 |
| SGK1 | phosphorylation up-regulates → | FOXO PThr32 | phosphorylation down-regulates ⊣ | FOXO | 11154281 | SIGNOR-252988 |
| SGK1 | phosphorylation up-regulates → | NDRG1 PThr356 | phosphorylation up-regulates → | NDRG1 | 18787837 | SIGNOR-180825 |
| SGK1 | phosphorylation up-regulates → | MAP3K3 PSer337 | phosphorylation down-regulates ⊣ | MAP3K3 | 12761205 | SIGNOR-101216 |
| SGK1 | phosphorylation up-regulates → | TSC2 PSer1132 | phosphorylation down-regulates ⊣ | TSC2 | 27451907 | SIGNOR-277265 |
| SGK1 | phosphorylation up-regulates → | WNK4 PSer1201 | phosphorylation up-regulates → | WNK4 | 23054253 | SIGNOR-276421 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SGK1 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252987 |
| SGK1 | phosphorylation → up-regulates activity | NR3C1 | SIGNOR-251669 |
| SGK1 | phosphorylation → down-regulates quantity | NCSTN | SIGNOR-280122 |
| SGK1 | phosphorylation → up-regulates activity | SLC9A1 | SIGNOR-280123 |
| SGK1 | phosphorylation → up-regulates activity | SP1 | SIGNOR-279246 |
| SGK1 | phosphorylation → up-regulates activity | MAPK1 | SIGNOR-276223 |
| SGK1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-236607 |
| SGK1 | phosphorylation → down-regulates activity | MKNK1 | SIGNOR-277357 |
| SGK1 | phosphorylation → up-regulates | NDRG2 | SIGNOR-129672 |
| SGK1 | phosphorylation → up-regulates | NEDD4L | SIGNOR-113052 |
| SGK1 | phosphorylation → down-regulates activity | MAP3K3 | SIGNOR-250005 |
| SGK1 | phosphorylation down-regulates | MAPT | SIGNOR-161288 |
| SGK1 | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-279386 |
| SGK1 | phosphorylation → down-regulates activity | TSC2 | SIGNOR-277266 |
| SGK1 | phosphorylation → down-regulates activity | MLLT3 | SIGNOR-279111 |
| SGK1 | phosphorylation → up-regulates | NDRG1 | SIGNOR-180829 |
| SGK1 | phosphorylation → down-regulates activity | NEDD4L | SIGNOR-251949 |
| SGK1 | phosphorylation → up-regulates activity | NR3C1 | SIGNOR-251670 |
| SGK1 | phosphorylation → down-regulates activity | MAP3K3 | SIGNOR-250004 |
| SGK1 | phosphorylation → up-regulates | FBXW7 | SIGNOR-170404 |
| SGK1 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252989 |
| SGK1 | phosphorylation → up-regulates | NDRG2 | SIGNOR-129680 |
| SGK1 | phosphorylation → down-regulates activity | FOXO1 | SIGNOR-255925 |
| SGK1 | phosphorylation → down-regulates activity | CDKN1B | SIGNOR-179121 |
| SGK1 | phosphorylation down-regulates | CDKN1B | SIGNOR-179117 |
| SGK1 | phosphorylation → up-regulates activity | STAT1 | SIGNOR-279281 |
| SGK1 | phosphorylation → up-regulates activity | SLC9A3 | SIGNOR-279112 |
| SGK1 | phosphorylation down-regulates quantity by destabilization | NCSTN | SIGNOR-276415 |
| SGK1 | phosphorylation → down-regulates activity | APBB1 | SIGNOR-278220 |
| SGK1 | phosphorylation → down-regulates activity | KMT2D | SIGNOR-277447 |
| SGK1 | phosphorylation → up-regulates activity | CHUK | SIGNOR-278987 |
| SGK1 | phosphorylation → down-regulates quantity | VDAC1 | SIGNOR-278988 |
| SGK1 | phosphorylation → down-regulates activity | WNK4 | SIGNOR-278453 |
| SGK1 | phosphorylation → down-regulates activity | MAP3K3 | SIGNOR-101211 |
| SGK1 | phosphorylation → up-regulates activity | SLC1A3 | SIGNOR-263075 |
| SGK1 | phosphorylation → down-regulates activity | BRAF | SIGNOR-279110 |
| SGK1 | phosphorylation down-regulates | HTT | SIGNOR-121349 |
| SGK1 | phosphorylation down-regulates | NDRG1 | SIGNOR-164898 |
| SGK1 | phosphorylation → up-regulates | NDRG1 | SIGNOR-180821 |
| SGK1 | phosphorylation → up-regulates activity | SLC2A4 | SIGNOR-236653 |
| SGK1 | phosphorylation down-regulates | NEDD4L | SIGNOR-133438 |
| SGK1 | phosphorylation → down-regulates activity | WNK4 | SIGNOR-278454 |
| SGK1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-249134 |
| SGK1 | phosphorylation → up-regulates | NDRG2 | SIGNOR-129676 |
| SGK1 | phosphorylation → down-regulates activity | MKNK1 | SIGNOR-277357 |
| SGK1 | phosphorylation → down-regulates activity | FOXO3 | SIGNOR-249133 |
| SGK1 | phosphorylation → down-regulates activity | NEDD4L | SIGNOR-263076 |
| SGK1 | phosphorylation → down-regulates activity | FOXO | SIGNOR-252988 |
| SGK1 | phosphorylation → up-regulates | NDRG1 | SIGNOR-180825 |
| SGK1 | phosphorylation → down-regulates activity | MAP3K3 | SIGNOR-101216 |
| SGK1 | phosphorylation → down-regulates activity | TSC2 | SIGNOR-277265 |
| SGK1 | phosphorylation → up-regulates activity | WNK4 | SIGNOR-276421 |