| Name | SGK1 |
| ID | O00141 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 98-355 PROSITE-ProRule
AGC-kinase C-terminal 356-431 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | SGK1 | Ser422 | AEAFLGFsYAPPTDS | phosphorylation up-regulates | 18925875 | SIGNOR-181531 |
| PDPK1 | SGK1 | Thr256 | EHNSTTStFCGTPEY | phosphorylation up-regulates | 15209375 | SIGNOR-236637 |
| PDPK1 | SGK1 | Ser422 | AEAFLGFsYAPPTDS | phosphorylation up-regulates activity | 10191262 | SIGNOR-250274 |
| PRKACA | SGK1 | Thr369 | DLINKKItPPFNPNV | phosphorylation up-regulates activity | 11096081 | SIGNOR-275972 |
| PDPK1 | SGK1 | Thr256 | EHNSTTStFCGTPEY | phosphorylation up-regulates | 10191262 | SIGNOR-236796 |
| PDPK2P | SGK1 | Thr256 | EHNSTTStFCGTPEY | phosphorylation up-regulates | 10191262 | SIGNOR-66234 |
| MAPK7 | SGK1 | Ser78 | ANPSPPPsPSQQINL | phosphorylation up-regulates | 11254654 | SIGNOR-105728 |
| MTOR | SGK1 | Ser422 | AEAFLGFsYAPPTDS | phosphorylation up-regulates | 18570873 | SIGNOR-179113 |
| mTORC1 | SGK1 | Ser422 | AEAFLGFsYAPPTDS | phosphorylation up-regulates activity | 18570873 | SIGNOR-217078 |
| PDPK1 | SGK1 | Thr256 | EHNSTTStFCGTPEY | phosphorylation up-regulates | 12387817 | SIGNOR-236800 |
| NEK6 | SGK1 | Ser422 | AEAFLGFsYAPPTDS | phosphorylation up-regulates activity | 12023960 | SIGNOR-250297 |
| mTORC2 | SGK1 | Ser422 | AEAFLGFsYAPPTDS | phosphorylation up-regulates | 18925875 | SIGNOR-217016 |
| NEK6 | SGK1 | Ser377 | PPFNPNVsGPNDLRH | phosphorylation up-regulates activity | 12023960 | SIGNOR-262954 |
| NEK6 | SGK1 | Ser377 | PPFNPNVsGPNDLRH | phosphorylation up-regulates activity | 12023960 | SIGNOR-250296 |
| PDPK1 | SGK1 | Thr256 | EHNSTTStFCGTPEY | phosphorylation up-regulates activity | 10191262 | SIGNOR-250275 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | phosphorylation up-regulates → | SGK1 PSer422 | phosphorylation up-regulates → | SGK1 | 18925875 | SIGNOR-181531 |
| PDPK1 | phosphorylation up-regulates → | SGK1 PThr256 | phosphorylation up-regulates → | SGK1 | 15209375 | SIGNOR-236637 |
| PDPK1 | phosphorylation up-regulates → | SGK1 PSer422 | phosphorylation up-regulates → | SGK1 | 10191262 | SIGNOR-250274 |
| PRKACA | phosphorylation up-regulates → | SGK1 PThr369 | phosphorylation up-regulates → | SGK1 | 11096081 | SIGNOR-275972 |
| PDPK1 | phosphorylation up-regulates → | SGK1 PThr256 | phosphorylation up-regulates → | SGK1 | 10191262 | SIGNOR-236796 |
| PDPK2P | phosphorylation up-regulates → | SGK1 PThr256 | phosphorylation up-regulates → | SGK1 | 10191262 | SIGNOR-66234 |
| MAPK7 | phosphorylation up-regulates → | SGK1 PSer78 | phosphorylation up-regulates → | SGK1 | 11254654 | SIGNOR-105728 |
| MTOR | phosphorylation up-regulates → | SGK1 PSer422 | phosphorylation up-regulates → | SGK1 | 18570873 | SIGNOR-179113 |
| mTORC1 | phosphorylation up-regulates → | SGK1 PSer422 | phosphorylation up-regulates → | SGK1 | 18570873 | SIGNOR-217078 |
| PDPK1 | phosphorylation up-regulates → | SGK1 PThr256 | phosphorylation up-regulates → | SGK1 | 12387817 | SIGNOR-236800 |
| NEK6 | phosphorylation up-regulates → | SGK1 PSer422 | phosphorylation up-regulates → | SGK1 | 12023960 | SIGNOR-250297 |
| mTORC2 | phosphorylation up-regulates → | SGK1 PSer422 | phosphorylation up-regulates → | SGK1 | 18925875 | SIGNOR-217016 |
| NEK6 | phosphorylation up-regulates → | SGK1 PSer377 | phosphorylation up-regulates → | SGK1 | 12023960 | SIGNOR-262954 |
| NEK6 | phosphorylation up-regulates → | SGK1 PSer377 | phosphorylation up-regulates → | SGK1 | 12023960 | SIGNOR-250296 |
| PDPK1 | phosphorylation up-regulates → | SGK1 PThr256 | phosphorylation up-regulates → | SGK1 | 10191262 | SIGNOR-250275 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MTOR | phosphorylation → up-regulates | SGK1 | SIGNOR-181531 |
| PDPK1 | phosphorylation → up-regulates | SGK1 | SIGNOR-236637 |
| PDPK1 | phosphorylation → up-regulates activity | SGK1 | SIGNOR-250274 |
| PRKACA | phosphorylation → up-regulates activity | SGK1 | SIGNOR-275972 |
| PDPK1 | phosphorylation → up-regulates | SGK1 | SIGNOR-236796 |
| PDPK2P | phosphorylation → up-regulates | SGK1 | SIGNOR-66234 |
| MAPK7 | phosphorylation → up-regulates | SGK1 | SIGNOR-105728 |
| MTOR | phosphorylation → up-regulates | SGK1 | SIGNOR-179113 |
| mTORC1 | phosphorylation → up-regulates activity | SGK1 | SIGNOR-217078 |
| PDPK1 | phosphorylation → up-regulates | SGK1 | SIGNOR-236800 |
| NEK6 | phosphorylation → up-regulates activity | SGK1 | SIGNOR-250297 |
| mTORC2 | phosphorylation → up-regulates | SGK1 | SIGNOR-217016 |
| NEK6 | phosphorylation → up-regulates activity | SGK1 | SIGNOR-262954 |
| NEK6 | phosphorylation → up-regulates activity | SGK1 | SIGNOR-250296 |
| PDPK1 | phosphorylation → up-regulates activity | SGK1 | SIGNOR-250275 |