| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| mTORC1 | SGK1 | Ser422 | AEAFLGFsYAPPTDS | phosphorylation up-regulates activity | 18570873 | SIGNOR-217078 |
| NEK6 | SGK1 | Ser422 | AEAFLGFsYAPPTDS | phosphorylation up-regulates activity | 12023960 | SIGNOR-250297 |
| mTORC2 | SGK1 | Ser422 | AEAFLGFsYAPPTDS | phosphorylation up-regulates | 18925875 | SIGNOR-217016 |
| MTOR | SGK1 | Ser422 | AEAFLGFsYAPPTDS | phosphorylation up-regulates | 18925875 | SIGNOR-181531 |
| PDPK1 | SGK1 | Ser422 | AEAFLGFsYAPPTDS | phosphorylation up-regulates activity | 10191262 | SIGNOR-250274 |
| MTOR | SGK1 | Ser422 | AEAFLGFsYAPPTDS | phosphorylation up-regulates | 18570873 | SIGNOR-179113 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| mTORC1 | phosphorylation up-regulates → | SGK1 PSer422 | phosphorylation up-regulates → | SGK1 | 18570873 | SIGNOR-217078 |
| NEK6 | phosphorylation up-regulates → | SGK1 PSer422 | phosphorylation up-regulates → | SGK1 | 12023960 | SIGNOR-250297 |
| mTORC2 | phosphorylation up-regulates → | SGK1 PSer422 | phosphorylation up-regulates → | SGK1 | 18925875 | SIGNOR-217016 |
| MTOR | phosphorylation up-regulates → | SGK1 PSer422 | phosphorylation up-regulates → | SGK1 | 18925875 | SIGNOR-181531 |
| PDPK1 | phosphorylation up-regulates → | SGK1 PSer422 | phosphorylation up-regulates → | SGK1 | 10191262 | SIGNOR-250274 |
| MTOR | phosphorylation up-regulates → | SGK1 PSer422 | phosphorylation up-regulates → | SGK1 | 18570873 | SIGNOR-179113 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| mTORC1 | phosphorylation → up-regulates activity | SGK1 | SIGNOR-217078 |
| NEK6 | phosphorylation → up-regulates activity | SGK1 | SIGNOR-250297 |
| mTORC2 | phosphorylation → up-regulates | SGK1 | SIGNOR-217016 |
| MTOR | phosphorylation → up-regulates | SGK1 | SIGNOR-181531 |
| PDPK1 | phosphorylation → up-regulates activity | SGK1 | SIGNOR-250274 |
| MTOR | phosphorylation → up-regulates | SGK1 | SIGNOR-179113 |
