Entity Details

Name	mTORC1_Ser422
ID	O00141
Role	residue
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Data Summary

PTM Format

SIGNOR Summary

Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MTOR	SGK1	Ser422	AEAFLGFsYAPPTDS	phosphorylation up-regulates	18925875	SIGNOR-181531
PDPK1	SGK1	Ser422	AEAFLGFsYAPPTDS	phosphorylation up-regulates activity	10191262	SIGNOR-250274
MTOR	SGK1	Ser422	AEAFLGFsYAPPTDS	phosphorylation up-regulates	18570873	SIGNOR-179113
mTORC1	SGK1	Ser422	AEAFLGFsYAPPTDS	phosphorylation up-regulates activity	18570873	SIGNOR-217078
NEK6	SGK1	Ser422	AEAFLGFsYAPPTDS	phosphorylation up-regulates activity	12023960	SIGNOR-250297
mTORC2	SGK1	Ser422	AEAFLGFsYAPPTDS	phosphorylation up-regulates	18925875	SIGNOR-217016

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MTOR	phosphorylation up-regulates →	SGK1 PSer422	phosphorylation up-regulates →	SGK1	18925875	SIGNOR-181531
PDPK1	phosphorylation up-regulates →	SGK1 PSer422	phosphorylation up-regulates →	SGK1	10191262	SIGNOR-250274
MTOR	phosphorylation up-regulates →	SGK1 PSer422	phosphorylation up-regulates →	SGK1	18570873	SIGNOR-179113
mTORC1	phosphorylation up-regulates →	SGK1 PSer422	phosphorylation up-regulates →	SGK1	18570873	SIGNOR-217078
NEK6	phosphorylation up-regulates →	SGK1 PSer422	phosphorylation up-regulates →	SGK1	12023960	SIGNOR-250297
mTORC2	phosphorylation up-regulates →	SGK1 PSer422	phosphorylation up-regulates →	SGK1	18925875	SIGNOR-217016

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MTOR	phosphorylation → up-regulates	SGK1	SIGNOR-181531
PDPK1	phosphorylation → up-regulates activity	SGK1	SIGNOR-250274
MTOR	phosphorylation → up-regulates	SGK1	SIGNOR-179113
mTORC1	phosphorylation → up-regulates activity	SGK1	SIGNOR-217078
NEK6	phosphorylation → up-regulates activity	SGK1	SIGNOR-250297
mTORC2	phosphorylation → up-regulates	SGK1	SIGNOR-217016