| Name | TLR4 |
| ID | O00206 |
| Role | kinase |
| Enzymatic Domains |
LRRCT 579-629
TIR 672-815 PROSITE-ProRule |
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|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| TLR4 | MAPK14 | – | phosphorylation up-regulates activity | 28137827 | SIGNOR-263652 | |
| TLR4 | ERK1/2 | – | phosphorylation up-regulates activity | 28137827 | SIGNOR-261930 | |
| TLR4 | JNK | – | phosphorylation up-regulates activity | 28137827 | SIGNOR-261929 | |
| TLR4 | p38 | – | phosphorylation up-regulates activity | 28137827 | SIGNOR-261928 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| TLR4 | phosphorylation → up-regulates activity | MAPK14 | SIGNOR-263652 |
| TLR4 | phosphorylation → up-regulates activity | ERK1/2 | SIGNOR-261930 |
| TLR4 | phosphorylation → up-regulates activity | JNK | SIGNOR-261929 |
| TLR4 | phosphorylation → up-regulates activity | p38 | SIGNOR-261928 |