| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK11B | EIF3F | Ser46 | PAAAPASsSDPAAAA | phosphorylation up-regulates activity | 19245811 | SIGNOR-273133 |
| CDK11B | EIF3F | Ser46 | PAAAPASsSDPAAAA | phosphorylation down-regulates | 12446680 | SIGNOR-95762 |
| CyclinD3/CDK11B | EIF3F | Ser46 | PAAAPASsSDPAAAA | phosphorylation up-regulates activity | 19245811 | SIGNOR-273134 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK11B | phosphorylation up-regulates → | EIF3F PSer46 | phosphorylation up-regulates → | EIF3F | 19245811 | SIGNOR-273133 |
| CDK11B | phosphorylation up-regulates → | EIF3F PSer46 | phosphorylation down-regulates ⊣ | EIF3F | 12446680 | SIGNOR-95762 |
| CyclinD3/CDK11B | phosphorylation up-regulates → | EIF3F PSer46 | phosphorylation up-regulates → | EIF3F | 19245811 | SIGNOR-273134 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK11B | phosphorylation → up-regulates activity | EIF3F | SIGNOR-273133 |
| CDK11B | phosphorylation down-regulates | EIF3F | SIGNOR-95762 |
| CyclinD3/CDK11B | phosphorylation → up-regulates activity | EIF3F | SIGNOR-273134 |
