| Name | CDC7 |
| ID | O00311 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 58-574 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC7 | PSIP1 | Ser206 | MVKQPCPsESDIITE | phosphorylation up-regulates | 7231784 | SIGNOR-25763 |
| CDC7 | MCM4 | – | phosphorylation up-regulates | 21070963 | SIGNOR-169453 | |
| CDC7 | MCM7 | – | phosphorylation up-regulates | 21070963 | SIGNOR-169506 | |
| CDC7 | MCM2 | Ser13 | ESFTMASsPAQRRRG | phosphorylation up-regulates | 16446360 | SIGNOR-143984 |
| CDC7 | MCM2 | Ser139 | RRGLLYDsDEEDEER | phosphorylation up-regulates | 16446360 | SIGNOR-143988 |
| CDC7 | MCM2 | Ser27 | GNDPLTSsPGRSSRR | phosphorylation up-regulates | 16446360 | SIGNOR-143992 |
| CDC7 | MCM2 | Ser41 | RTDALTSsPGRDLPP | phosphorylation up-regulates | 16446360 | SIGNOR-143996 |
| CDC7 | MCM2 | Ser139 | RRGLLYDsDEEDEER | phosphorylation up-regulates | 16899510 | SIGNOR-148709 |
| CDC7 | MCM2 | Ser27 | GNDPLTSsPGRSSRR | phosphorylation up-regulates | 16899510 | SIGNOR-148713 |
| CDC7 | MCM2 | Ser41 | RTDALTSsPGRDLPP | phosphorylation up-regulates | 16899510 | SIGNOR-148717 |
| CDC7 | MCM2 | Ser108 | DVEELTAsQREAAER | phosphorylation up-regulates | 19647517 | SIGNOR-187388 |
| CDC7 | MCM2 | Ser40 | RRTDALTsSPGRDLP | phosphorylation up-regulates | 19647517 | SIGNOR-187392 |
| CDC7 | MCM2 | Ser5 | sESFTMAS | phosphorylation up-regulates | 19647517 | SIGNOR-187396 |
| CDC7 | MCM2 | Ser53 | LPPFEDEsEGLLGTE | phosphorylation up-regulates | 19647517 | SIGNOR-187400 |
| CDC7 | TARDBP | Ser409 | GSSMDSKsSGWGM | phosphorylation up-regulates activity | 23424178 | SIGNOR-278256 |
| CDC7 | TARDBP | Ser410 | SSMDSKSsGWGM | phosphorylation up-regulates activity | 23424178 | SIGNOR-278257 |
| CDC7 | ESCO1 | – | phosphorylation down-regulates | 23314252 | SIGNOR-200397 | |
| CDC7 | DTD1 | Ser179 | KTRAKGPsESSKERN | phosphorylation up-regulates activity | 25258324 | SIGNOR-273968 |
| CDC7 | DTD1 | Ser181 | RAKGPSEsSKERNTP | phosphorylation up-regulates activity | 25258324 | SIGNOR-273966 |
| CDC7 | DTD1 | Ser182 | AKGPSESsKERNTPR | phosphorylation up-regulates activity | 25258324 | SIGNOR-273967 |
| CDC7 | DTD1 | Ser194 | TPRKEDRsASSGAEG | phosphorylation up-regulates activity | 25258324 | SIGNOR-273961 |
| CDC7 | DTD1 | Ser196 | RKEDRSAsSGAEGDV | phosphorylation up-regulates activity | 25258324 | SIGNOR-273962 |
| CDC7 | DTD1 | Ser197 | KEDRSASsGAEGDVS | phosphorylation up-regulates activity | 25258324 | SIGNOR-273963 |
| CDC7 | DTD1 | Ser204 | SGAEGDVsSEREP | phosphorylation up-regulates activity | 25258324 | SIGNOR-273965 |
| CDC7 | DTD1 | Ser205 | GAEGDVSsEREP | phosphorylation up-regulates activity | 25258324 | SIGNOR-273969 |
| CDC7 | DTD1 | Thr187 | ESSKERNtPRKEDRS | phosphorylation up-regulates activity | 25258324 | SIGNOR-273964 |
| CDC7 | CDC5L | – | phosphorylation down-regulates activity | 32099015 | SIGNOR-280203 | |
| CDC7 | CLSPN | – | phosphorylation up-regulates activity | 27401717 | SIGNOR-279360 | |
| CDC7 | RAD18 | Ser434 | IQEVLSSsESDSCNS | phosphorylation unknown | 21098111 | SIGNOR-170049 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDC7 | phosphorylation up-regulates → | PSIP1 PSer206 | phosphorylation up-regulates → | PSIP1 | 7231784 | SIGNOR-25763 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer13 | phosphorylation up-regulates → | MCM2 | 16446360 | SIGNOR-143984 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer139 | phosphorylation up-regulates → | MCM2 | 16446360 | SIGNOR-143988 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer27 | phosphorylation up-regulates → | MCM2 | 16446360 | SIGNOR-143992 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer41 | phosphorylation up-regulates → | MCM2 | 16446360 | SIGNOR-143996 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer139 | phosphorylation up-regulates → | MCM2 | 16899510 | SIGNOR-148709 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer27 | phosphorylation up-regulates → | MCM2 | 16899510 | SIGNOR-148713 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer41 | phosphorylation up-regulates → | MCM2 | 16899510 | SIGNOR-148717 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer108 | phosphorylation up-regulates → | MCM2 | 19647517 | SIGNOR-187388 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer40 | phosphorylation up-regulates → | MCM2 | 19647517 | SIGNOR-187392 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer5 | phosphorylation up-regulates → | MCM2 | 19647517 | SIGNOR-187396 |
| CDC7 | phosphorylation up-regulates → | MCM2 PSer53 | phosphorylation up-regulates → | MCM2 | 19647517 | SIGNOR-187400 |
| CDC7 | phosphorylation up-regulates → | TARDBP PSer409 | phosphorylation up-regulates → | TARDBP | 23424178 | SIGNOR-278256 |
| CDC7 | phosphorylation up-regulates → | TARDBP PSer410 | phosphorylation up-regulates → | TARDBP | 23424178 | SIGNOR-278257 |
| CDC7 | phosphorylation up-regulates → | DTD1 PSer179 | phosphorylation up-regulates → | DTD1 | 25258324 | SIGNOR-273968 |
| CDC7 | phosphorylation up-regulates → | DTD1 PSer181 | phosphorylation up-regulates → | DTD1 | 25258324 | SIGNOR-273966 |
| CDC7 | phosphorylation up-regulates → | DTD1 PSer182 | phosphorylation up-regulates → | DTD1 | 25258324 | SIGNOR-273967 |
| CDC7 | phosphorylation up-regulates → | DTD1 PSer194 | phosphorylation up-regulates → | DTD1 | 25258324 | SIGNOR-273961 |
| CDC7 | phosphorylation up-regulates → | DTD1 PSer196 | phosphorylation up-regulates → | DTD1 | 25258324 | SIGNOR-273962 |
| CDC7 | phosphorylation up-regulates → | DTD1 PSer197 | phosphorylation up-regulates → | DTD1 | 25258324 | SIGNOR-273963 |
| CDC7 | phosphorylation up-regulates → | DTD1 PSer204 | phosphorylation up-regulates → | DTD1 | 25258324 | SIGNOR-273965 |
| CDC7 | phosphorylation up-regulates → | DTD1 PSer205 | phosphorylation up-regulates → | DTD1 | 25258324 | SIGNOR-273969 |
| CDC7 | phosphorylation up-regulates → | DTD1 PThr187 | phosphorylation up-regulates → | DTD1 | 25258324 | SIGNOR-273964 |
| CDC7 | phosphorylation up-regulates → | RAD18 PSer434 | phosphorylation down-regulates ⊣ | RAD18 | 21098111 | SIGNOR-170049 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDC7 | phosphorylation → up-regulates | PSIP1 | SIGNOR-25763 |
| CDC7 | phosphorylation → up-regulates | MCM4 | SIGNOR-169453 |
| CDC7 | phosphorylation → up-regulates | MCM7 | SIGNOR-169506 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-143984 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-143988 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-143992 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-143996 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-148709 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-148713 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-148717 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-187388 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-187392 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-187396 |
| CDC7 | phosphorylation → up-regulates | MCM2 | SIGNOR-187400 |
| CDC7 | phosphorylation → up-regulates activity | TARDBP | SIGNOR-278256 |
| CDC7 | phosphorylation → up-regulates activity | TARDBP | SIGNOR-278257 |
| CDC7 | phosphorylation down-regulates | ESCO1 | SIGNOR-200397 |
| CDC7 | phosphorylation → up-regulates activity | DTD1 | SIGNOR-273968 |
| CDC7 | phosphorylation → up-regulates activity | DTD1 | SIGNOR-273966 |
| CDC7 | phosphorylation → up-regulates activity | DTD1 | SIGNOR-273967 |
| CDC7 | phosphorylation → up-regulates activity | DTD1 | SIGNOR-273961 |
| CDC7 | phosphorylation → up-regulates activity | DTD1 | SIGNOR-273962 |
| CDC7 | phosphorylation → up-regulates activity | DTD1 | SIGNOR-273963 |
| CDC7 | phosphorylation → up-regulates activity | DTD1 | SIGNOR-273965 |
| CDC7 | phosphorylation → up-regulates activity | DTD1 | SIGNOR-273969 |
| CDC7 | phosphorylation → up-regulates activity | DTD1 | SIGNOR-273964 |
| CDC7 | phosphorylation → down-regulates activity | CDC5L | SIGNOR-280203 |
| CDC7 | phosphorylation → up-regulates activity | CLSPN | SIGNOR-279360 |
| CDC7 | phosphorylation → unknown | RAD18 | SIGNOR-170049 |