Entity Details

Name CDC7
ID O00311
Role substrate
Enzymatic Domains
Protein kinase 58-574
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK1CDC7Thr376QVAPRAGtPGFRAPEphosphorylation
up-regulates		10846177SIGNOR-78311
CyclinA2/CDK2CDC7Thr376QVAPRAGtPGFRAPEphosphorylation
up-regulates activity		10846177SIGNOR-250725
CyclinE/CDK2CDC7Thr376QVAPRAGtPGFRAPEphosphorylation
up-regulates activity		10846177SIGNOR-250726
CHEK1CDC7–phosphorylation
up-regulates		20068082SIGNOR-163161
CyclinB/CDK1CDC7Thr376QVAPRAGtPGFRAPEphosphorylation
up-regulates activity		10846177SIGNOR-250643
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK1phosphorylation
up-regulates
→
CDC7
PThr376		phosphorylation
up-regulates
→		CDC710846177SIGNOR-78311
CyclinA2/CDK2phosphorylation
up-regulates
→
CDC7
PThr376		phosphorylation
up-regulates
→		CDC710846177SIGNOR-250725
CyclinE/CDK2phosphorylation
up-regulates
→
CDC7
PThr376		phosphorylation
up-regulates
→		CDC710846177SIGNOR-250726
CyclinB/CDK1phosphorylation
up-regulates
→
CDC7
PThr376		phosphorylation
up-regulates
→		CDC710846177SIGNOR-250643
Regulator Mechanism/Effect Target SIGNOR-ID
CDK1phosphorylation
→
up-regulates 		CDC7SIGNOR-78311
CyclinA2/CDK2phosphorylation
→
up-regulates activity 		CDC7SIGNOR-250725
CyclinE/CDK2phosphorylation
→
up-regulates activity 		CDC7SIGNOR-250726
CHEK1phosphorylation
→
up-regulates 		CDC7SIGNOR-163161
CyclinB/CDK1phosphorylation
→
up-regulates activity 		CDC7SIGNOR-250643