| Name | WASL |
| ID | O00401 |
| Role | substrate |
| Enzymatic Domains |
WH1 34-141 PROSITE-ProRule
CRIB 203-216 PROSITE-ProRule
WH2 1 405-422 PROSITE-ProRule
WH2 2 433-450 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTK2 | WASL | – | phosphorylation up-regulates activity | 24290759 | SIGNOR-278977 | |
| ABL1 | WASL | Tyr256 | RETSKVIyDFIEKTG | phosphorylation up-regulates activity | 16199863 | SIGNOR-251437 |
| PTPN2 | WASL | Tyr256 | RETSKVIyDFIEKTG | dephosphorylation down-regulates | 16293614 | SIGNOR-141652 |
| SRC | WASL | – | phosphorylation up-regulates activity | 15791211 | SIGNOR-279487 | |
| ABL1 | WASL | Tyr175 | EITTNRFyGPQVNNI | phosphorylation up-regulates activity | 16199863 | SIGNOR-251436 |
| ABL1 | WASL | Tyr175 | EITTNRFyGPQVNNI | phosphorylation unknown | 16199863 | SIGNOR-247666 |
| TNK2 | WASL | – | phosphorylation up-regulates activity | 31769754 | SIGNOR-280155 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ABL1 | phosphorylation up-regulates → | WASL PTyr256 | phosphorylation up-regulates → | WASL | 16199863 | SIGNOR-251437 |
| PTPN2 | dephosphorylation down-regulates ⊣ | WASL PTyr256 | dephosphorylation up-regulates → | WASL | 16293614 | SIGNOR-141652 |
| ABL1 | phosphorylation up-regulates → | WASL PTyr175 | phosphorylation up-regulates → | WASL | 16199863 | SIGNOR-251436 |
| ABL1 | phosphorylation up-regulates → | WASL PTyr175 | phosphorylation down-regulates ⊣ | WASL | 16199863 | SIGNOR-247666 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTK2 | phosphorylation → up-regulates activity | WASL | SIGNOR-278977 |
| ABL1 | phosphorylation → up-regulates activity | WASL | SIGNOR-251437 |
| PTPN2 | dephosphorylation down-regulates | WASL | SIGNOR-141652 |
| SRC | phosphorylation → up-regulates activity | WASL | SIGNOR-279487 |
| ABL1 | phosphorylation → up-regulates activity | WASL | SIGNOR-251436 |
| ABL1 | phosphorylation → unknown | WASL | SIGNOR-247666 |
| TNK2 | phosphorylation → up-regulates activity | WASL | SIGNOR-280155 |