| Name | DNM1L |
| ID | O00429 |
| Role | substrate |
| Enzymatic Domains |
Dynamin-type G 22-302 PROSITE-ProRule
GED 644-735 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP3CA | DNM1L | Ser637 | VPVARKLsAREQRDC | dephosphorylation up-regulates activity | 18838687 | SIGNOR-248676 |
| GSK3B | DNM1L | Ser40 | TQSSGKSsVLESLVG | phosphorylation up-regulates activity | 25192600 | SIGNOR-276849 |
| GSK3B | DNM1L | Ser44 | GKSSVLEsLVGRDLL | phosphorylation up-regulates activity | 25192600 | SIGNOR-276848 |
| ABL1 | DNM1L | Tyr449 | IIQHCSNySTQELLR | phosphorylation up-regulates activity | 29022905 | SIGNOR-278463 |
| PP2B | DNM1L | – | dephosphorylation up-regulates activity | 18838687 | SIGNOR-269994 | |
| PPP3CC | DNM1L | Ser637 | VPVARKLsAREQRDC | dephosphorylation up-regulates activity | 18838687 | SIGNOR-248506 |
| ERK1/2 | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates activity | 25658205 | SIGNOR-275407 |
| ABL1 | DNM1L | Tyr266 | TDSIRDEyAFLQKKY | phosphorylation up-regulates activity | 29022905 | SIGNOR-277328 |
| CDK5 | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates activity | 25730670 | SIGNOR-278275 |
| ABL1 | DNM1L | Tyr266 | TDSIRDEyAFLQKKY | phosphorylation up-regulates activity | 29022905 | SIGNOR-278462 |
| PINK1 | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates activity | 32484300 | SIGNOR-279548 |
| ABL1 | DNM1L | Tyr449 | IIQHCSNySTQELLR | phosphorylation up-regulates activity | 29022905 | SIGNOR-277327 |
| CyclinB/CDK1 | DNM1L | Ser585 | WRGMLKTSKAEELLA | phosphorylation up-regulates activity | 17301055 | SIGNOR-274131 |
| ABL1 | DNM1L | Tyr368 | CGGARICyIFHETFG | phosphorylation up-regulates activity | 29022905 | SIGNOR-277329 |
| PPP3CB | DNM1L | Ser637 | VPVARKLsAREQRDC | dephosphorylation up-regulates activity | 18838687 | SIGNOR-248361 |
| ROCK1 | DNM1L | Ser637 | VPVARKLsAREQRDC | phosphorylation up-regulates activity | 31063459 | SIGNOR-262549 |
| PKA | DNM1L | Ser637 | VPVARKLsAREQRDC | phosphorylation down-regulates activity | 31063459 | SIGNOR-262551 |
| Calcineurin | DNM1L | Ser637 | VPVARKLsAREQRDC | dephosphorylation up-regulates activity | 18838687 | SIGNOR-252315 |
| LRRK2 | DNM1L | Thr595 | NWRGMLKtSKAEELL | phosphorylation up-regulates activity | 23813973 | SIGNOR-276495 |
| MTOR | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates activity | 34535949 | SIGNOR-275430 |
| GSK3B | DNM1L | Ser44 | GKSSVLEsLVGRDLL | phosphorylation up-regulates activity | 25192600 | SIGNOR-278479 |
| GSK3B | DNM1L | Ser40 | TQSSGKSsVLESLVG | phosphorylation up-regulates activity | 25192600 | SIGNOR-278480 |
| CDK1 | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates activity | 26352374 | SIGNOR-279394 |
| CAMK1 | DNM1L | Ser637 | VPVARKLsAREQRDC | phosphorylation up-regulates activity | 31063459 | SIGNOR-262552 |
| GSK3B | DNM1L | Ser693 | LVGQLYKsSLLDDLL | phosphorylation down-regulates activity | 23185298 | SIGNOR-276430 |
| RIPK1 | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates activity | 34654937 | SIGNOR-280104 |
| PRKCD | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates | 17301055 | SIGNOR-153148 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP3CA | dephosphorylation down-regulates ⊣ | DNM1L PSer637 | dephosphorylation down-regulates ⊣ | DNM1L | 18838687 | SIGNOR-248676 |
| GSK3B | phosphorylation up-regulates → | DNM1L PSer40 | phosphorylation up-regulates → | DNM1L | 25192600 | SIGNOR-276849 |
| GSK3B | phosphorylation up-regulates → | DNM1L PSer44 | phosphorylation up-regulates → | DNM1L | 25192600 | SIGNOR-276848 |
| ABL1 | phosphorylation up-regulates → | DNM1L PTyr449 | phosphorylation up-regulates → | DNM1L | 29022905 | SIGNOR-278463 |
| PPP3CC | dephosphorylation down-regulates ⊣ | DNM1L PSer637 | dephosphorylation down-regulates ⊣ | DNM1L | 18838687 | SIGNOR-248506 |
| ERK1/2 | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 25658205 | SIGNOR-275407 |
| ABL1 | phosphorylation up-regulates → | DNM1L PTyr266 | phosphorylation up-regulates → | DNM1L | 29022905 | SIGNOR-277328 |
| CDK5 | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 25730670 | SIGNOR-278275 |
| ABL1 | phosphorylation up-regulates → | DNM1L PTyr266 | phosphorylation up-regulates → | DNM1L | 29022905 | SIGNOR-278462 |
| PINK1 | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 32484300 | SIGNOR-279548 |
| ABL1 | phosphorylation up-regulates → | DNM1L PTyr449 | phosphorylation up-regulates → | DNM1L | 29022905 | SIGNOR-277327 |
| CyclinB/CDK1 | phosphorylation up-regulates → | DNM1L PSer585 | phosphorylation up-regulates → | DNM1L | 17301055 | SIGNOR-274131 |
| ABL1 | phosphorylation up-regulates → | DNM1L PTyr368 | phosphorylation up-regulates → | DNM1L | 29022905 | SIGNOR-277329 |
| PPP3CB | dephosphorylation down-regulates ⊣ | DNM1L PSer637 | dephosphorylation down-regulates ⊣ | DNM1L | 18838687 | SIGNOR-248361 |
| ROCK1 | phosphorylation up-regulates → | DNM1L PSer637 | phosphorylation up-regulates → | DNM1L | 31063459 | SIGNOR-262549 |
| PKA | phosphorylation up-regulates → | DNM1L PSer637 | phosphorylation down-regulates ⊣ | DNM1L | 31063459 | SIGNOR-262551 |
| Calcineurin | dephosphorylation down-regulates ⊣ | DNM1L PSer637 | dephosphorylation down-regulates ⊣ | DNM1L | 18838687 | SIGNOR-252315 |
| LRRK2 | phosphorylation up-regulates → | DNM1L PThr595 | phosphorylation up-regulates → | DNM1L | 23813973 | SIGNOR-276495 |
| MTOR | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 34535949 | SIGNOR-275430 |
| GSK3B | phosphorylation up-regulates → | DNM1L PSer44 | phosphorylation up-regulates → | DNM1L | 25192600 | SIGNOR-278479 |
| GSK3B | phosphorylation up-regulates → | DNM1L PSer40 | phosphorylation up-regulates → | DNM1L | 25192600 | SIGNOR-278480 |
| CDK1 | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 26352374 | SIGNOR-279394 |
| CAMK1 | phosphorylation up-regulates → | DNM1L PSer637 | phosphorylation up-regulates → | DNM1L | 31063459 | SIGNOR-262552 |
| GSK3B | phosphorylation up-regulates → | DNM1L PSer693 | phosphorylation down-regulates ⊣ | DNM1L | 23185298 | SIGNOR-276430 |
| RIPK1 | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 34654937 | SIGNOR-280104 |
| PRKCD | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 17301055 | SIGNOR-153148 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP3CA | dephosphorylation → up-regulates activity | DNM1L | SIGNOR-248676 |
| GSK3B | phosphorylation → up-regulates activity | DNM1L | SIGNOR-276849 |
| GSK3B | phosphorylation → up-regulates activity | DNM1L | SIGNOR-276848 |
| ABL1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-278463 |
| PP2B | dephosphorylation → up-regulates activity | DNM1L | SIGNOR-269994 |
| PPP3CC | dephosphorylation → up-regulates activity | DNM1L | SIGNOR-248506 |
| ERK1/2 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-275407 |
| ABL1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-277328 |
| CDK5 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-278275 |
| ABL1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-278462 |
| PINK1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-279548 |
| ABL1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-277327 |
| CyclinB/CDK1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-274131 |
| ABL1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-277329 |
| PPP3CB | dephosphorylation → up-regulates activity | DNM1L | SIGNOR-248361 |
| ROCK1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-262549 |
| PKA | phosphorylation → down-regulates activity | DNM1L | SIGNOR-262551 |
| Calcineurin | dephosphorylation → up-regulates activity | DNM1L | SIGNOR-252315 |
| LRRK2 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-276495 |
| MTOR | phosphorylation → up-regulates activity | DNM1L | SIGNOR-275430 |
| GSK3B | phosphorylation → up-regulates activity | DNM1L | SIGNOR-278479 |
| GSK3B | phosphorylation → up-regulates activity | DNM1L | SIGNOR-278480 |
| CDK1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-279394 |
| CAMK1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-262552 |
| GSK3B | phosphorylation → down-regulates activity | DNM1L | SIGNOR-276430 |
| RIPK1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-280104 |
| PRKCD | phosphorylation → up-regulates | DNM1L | SIGNOR-153148 |