| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates activity | 34535949 | SIGNOR-275430 |
| CDK1 | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates activity | 26352374 | SIGNOR-279394 |
| RIPK1 | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates activity | 34654937 | SIGNOR-280104 |
| PRKCD | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates | 17301055 | SIGNOR-153148 |
| ERK1/2 | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates activity | 25658205 | SIGNOR-275407 |
| CDK5 | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates activity | 25730670 | SIGNOR-278275 |
| PINK1 | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates activity | 32484300 | SIGNOR-279548 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 34535949 | SIGNOR-275430 |
| CDK1 | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 26352374 | SIGNOR-279394 |
| RIPK1 | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 34654937 | SIGNOR-280104 |
| PRKCD | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 17301055 | SIGNOR-153148 |
| ERK1/2 | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 25658205 | SIGNOR-275407 |
| CDK5 | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 25730670 | SIGNOR-278275 |
| PINK1 | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 32484300 | SIGNOR-279548 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MTOR | phosphorylation → up-regulates activity | DNM1L | SIGNOR-275430 |
| CDK1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-279394 |
| RIPK1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-280104 |
| PRKCD | phosphorylation → up-regulates | DNM1L | SIGNOR-153148 |
| ERK1/2 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-275407 |
| CDK5 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-278275 |
| PINK1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-279548 |
