| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK1 | DNM1L | Ser637 | VPVARKLsAREQRDC | phosphorylation up-regulates activity | 31063459 | SIGNOR-262552 |
| PPP3CA | DNM1L | Ser637 | VPVARKLsAREQRDC | dephosphorylation up-regulates activity | 18838687 | SIGNOR-248676 |
| PPP3CC | DNM1L | Ser637 | VPVARKLsAREQRDC | dephosphorylation up-regulates activity | 18838687 | SIGNOR-248506 |
| PPP3CB | DNM1L | Ser637 | VPVARKLsAREQRDC | dephosphorylation up-regulates activity | 18838687 | SIGNOR-248361 |
| ROCK1 | DNM1L | Ser637 | VPVARKLsAREQRDC | phosphorylation up-regulates activity | 31063459 | SIGNOR-262549 |
| PKA | DNM1L | Ser637 | VPVARKLsAREQRDC | phosphorylation down-regulates activity | 31063459 | SIGNOR-262551 |
| Calcineurin | DNM1L | Ser637 | VPVARKLsAREQRDC | dephosphorylation up-regulates activity | 18838687 | SIGNOR-252315 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK1 | phosphorylation up-regulates → | DNM1L PSer637 | phosphorylation up-regulates → | DNM1L | 31063459 | SIGNOR-262552 |
| PPP3CA | dephosphorylation down-regulates ⊣ | DNM1L PSer637 | dephosphorylation down-regulates ⊣ | DNM1L | 18838687 | SIGNOR-248676 |
| PPP3CC | dephosphorylation down-regulates ⊣ | DNM1L PSer637 | dephosphorylation down-regulates ⊣ | DNM1L | 18838687 | SIGNOR-248506 |
| PPP3CB | dephosphorylation down-regulates ⊣ | DNM1L PSer637 | dephosphorylation down-regulates ⊣ | DNM1L | 18838687 | SIGNOR-248361 |
| ROCK1 | phosphorylation up-regulates → | DNM1L PSer637 | phosphorylation up-regulates → | DNM1L | 31063459 | SIGNOR-262549 |
| PKA | phosphorylation up-regulates → | DNM1L PSer637 | phosphorylation down-regulates ⊣ | DNM1L | 31063459 | SIGNOR-262551 |
| Calcineurin | dephosphorylation down-regulates ⊣ | DNM1L PSer637 | dephosphorylation down-regulates ⊣ | DNM1L | 18838687 | SIGNOR-252315 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAMK1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-262552 |
| PPP3CA | dephosphorylation → up-regulates activity | DNM1L | SIGNOR-248676 |
| PPP3CC | dephosphorylation → up-regulates activity | DNM1L | SIGNOR-248506 |
| PPP3CB | dephosphorylation → up-regulates activity | DNM1L | SIGNOR-248361 |
| ROCK1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-262549 |
| PKA | phosphorylation → down-regulates activity | DNM1L | SIGNOR-262551 |
| Calcineurin | dephosphorylation → up-regulates activity | DNM1L | SIGNOR-252315 |
