| Name | PIK3C2A |
| ID | O00443 |
| Role | substrate |
| Enzymatic Domains |
PI3K-RBD 421-509 PROSITE-ProRule
PIK helical 861-1037 PROSITE-ProRule
PI3K/PI4K catalytic 1105-1383 PROSITE-ProRule
PX 1422-1538 PROSITE-ProRule
C2 1555-1678 PROSITE-ProRule |
View in  |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | PIK3C2A | Ser259 | KVSNLQVsPKSEDIS | phosphorylation down-regulates activity | 12719431 | SIGNOR-100903 |
| IGF1R | PIK3C2A | – | phosphorylation up-regulates | 7692086 | SIGNOR-32076 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | PIK3C2A PSer259 | phosphorylation down-regulates ⊣ | PIK3C2A | 12719431 | SIGNOR-100903 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation → down-regulates activity | PIK3C2A | SIGNOR-100903 |
| IGF1R | phosphorylation → up-regulates | PIK3C2A | SIGNOR-32076 |